INT100371

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.42
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
endothelial cells 1
retinas 1
ganglion cell 1
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 8 99.54 Very High Very High Very High
cINOD 10 98.76 Very High Very High Very High
opioid receptor 2 97.48 Very High Very High Very High
narcan 1 95.72 Very High Very High Very High
antagonist 1 95.36 Very High Very High Very High
Intracerebroventricular 1 92.72 High High
Morphine 2 90.40 High High
ischemia 5 86.28 High High
Inflammation 2 75.00 Quite High
Pain 2 57.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.84 Very High Very High Very High
Hypoxia 10 99.82 Very High Very High Very High
Injury 18 99.68 Very High Very High Very High
Stress 116 99.32 Very High Very High Very High
Diabetes Mellitus 220 98.56 Very High Very High Very High
Ganglion Cysts 8 97.60 Very High Very High Very High
Wound Healing 1 93.84 High High
Death 3 88.28 High High
Cancer 6 87.36 High High
Cv General 4 Under Development 2 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is speculated that triggering of FLT-1 induces weak or undetectable ligand-dependent tyrosine phosphorylation in porcine aortic endothelial cells, whereas FLK-1 binding induces a strong response (28).
Positive_regulation (triggering) of FLT-1 in endothelial cells
1) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.35 Pain Relevance 0
In their study, increased Flt-1 mRNA levels detected by in situ hybridization were found in the ganglion cell and both nuclear layers of diabetic samples only.
Positive_regulation (increased) of Flt-1 mRNA in ganglion cell associated with ganglion cysts and diabetes mellitus
2) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.62 Pain Relevance 0
Opioids accelerate healing by up-regulating both endothelial and inducible nitric oxide synthase and the vascular endothelial-derived growth factor receptor Flk1 in the wounds.
Positive_regulation (up-regulating) of vascular endothelial-derived growth factor receptor Flk1 associated with injury and opioid
3) Confidence 0.49 Published 2005 Journal Wound Repair Regen Section Abstract Doc Link 15828941 Disease Relevance 0.97 Pain Relevance 1.06
Vegf-a and Flk-1 transcription was significantly downregulated 2.9- and 2.0-fold, respectively (PVegf-a = 0.030 and PFlk-1 = 0.028); however, Flt-1 was significantly upregulated 1.3-fold (PFlt-1 = 0.002) with IVTA treatment (Fig. 1B).
Positive_regulation (upregulated) of Flt-1
4) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.29 Pain Relevance 0
It is evident that VEGFR-1, VEGFR-2 and neuropilin-1 levels increase following shear stress conditions.


Positive_regulation (increase) of VEGFR-1 associated with stress
5) Confidence 0.24 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.47 Pain Relevance 0
Quantification of the above receptors showed a significant increase in VEGFR-1, VEGFR-2 and neuropilin-1 mRNA following shear stress.


Positive_regulation (increase) of VEGFR-1 associated with stress
6) Confidence 0.22 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC519024 Disease Relevance 0.49 Pain Relevance 0
We also provide evidence demonstrating that shear stress imposed on LECs in vitro is accompanied by a significant increases in VEGFR-1, VEGFR-2 and neuropilin-1 mRNA levels.
Positive_regulation (increases) of VEGFR-1 associated with stress
7) Confidence 0.22 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC519024 Disease Relevance 0.42 Pain Relevance 0
In contrast to the elevated levels of VEGF and FLK-1, FLT-1 expression was reduced by 37.5% in diabetic retinas (16.94 ± 0.76 vs. 27.09 ± 0.56 positive cells/mm, P < 0.0001) (Fig. 2C).
Positive_regulation (elevated) of FLT-1 in retinas associated with diabetes mellitus
8) Confidence 0.19 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.88 Pain Relevance 0
Because HIF-1alpha is the major trigger for hypoxia-induced activation of the VEGF and Flt-1 genes, this could explain how NSAIDs inhibit hypoxia-induced angiogenesis.
Positive_regulation (activation) of Flt-1 associated with hypoxia and cinod
9) Confidence 0.12 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.98 Pain Relevance 0.62
The up-regulation of Flt-1 further indicates that lansoprazole activates vascular epidermal growth factor-mediated controlled angiogenesis to repair gastric mucosa.
Positive_regulation (up-regulation) of Flt-1
10) Confidence 0.05 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18375387 Disease Relevance 0.67 Pain Relevance 0.21
VEGF is one of the signaling molecules that binds to its receptors on cell membrane, VEGFR1 and VEGFR2, initiating signaling pathways through Akt activation.
Positive_regulation (activation) of VEGFR1
11) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.27 Pain Relevance 0.13

General Comments

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