INT100372

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 24.33
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
retinas 7
endothelial cells 5
microglia 3
TMJ 2
blood 2
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 18 98.36 Very High Very High Very High
Snapping jaw 10 97.84 Very High Very High Very High
anesthesia 45 97.68 Very High Very High Very High
Inflammatory response 56 97.00 Very High Very High Very High
cytokine 73 93.68 High High
corticosteroid 115 92.60 High High
palliative 2 92.40 High High
antagonist 147 89.80 High High
metalloproteinase 55 89.44 High High
Inflammatory mediators 9 89.12 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 9 100.00 Very High Very High Very High
Diabetes Mellitus 881 99.84 Very High Very High Very High
Cancer 623 99.84 Very High Very High Very High
Glioma 264 99.36 Very High Very High Very High
Metastasis 15 98.74 Very High Very High Very High
Ganglion Cysts 33 98.68 Very High Very High Very High
Hypoxia 31 98.68 Very High Very High Very High
Prostate Cancer 5 98.52 Very High Very High Very High
Pancreatic Cancer 8 98.40 Very High Very High Very High
Temporomandibular Joint Syndrome 10 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative changes in Vegf-a, Flk-1, and Flt-1 mRNA expression.
Gene_expression (expression) of Flt-1 mRNA
1) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.26 Pain Relevance 0
We also show that IVTA does not alter physiological VEGF-A, FLK-1, and FLT-1 levels in the normal retina.
Gene_expression (levels) of FLT-1 in retina
2) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.66 Pain Relevance 0.05
Immunohistochemical detection of retinal VEGF-A, FLK-1, FLT-1, and albumin.
Gene_expression (detection) of FLT-1
3) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0 Pain Relevance 0
The expression of VEGF-A and its two receptors (FLK-1 and FLT-1) was found predominantly in the ganglion cell layer, inner nuclear layer, and outer plexiform layer of all four treatment groups.
Gene_expression (expression) of FLT-1 in inner nuclear layer associated with ganglion cysts
4) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.50 Pain Relevance 0
The expression of another VEGF receptor, FLT-1, was unexpectedly decreased in diabetic retinas and increased following IVTA treatment.
Gene_expression (expression) of FLT-1 in retinas associated with diabetes mellitus
5) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.49 Pain Relevance 0
By contrast, Flt-1 expression was decreased in early diabetic retinas but was upregulated following IVTA treatment.
Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
6) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.70 Pain Relevance 0
For detection of VEGF-A, FLK-1, and FLT-1, the sections were treated with antigen retrieval solution (Dako) at 90°C for 10 min, subsequently cooled to room temperature, and then quenched with H2O2 blocker.
Gene_expression (detection) of FLT-1
7) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0 Pain Relevance 0
Retinal protein expression of VEGF-A, FLK-1, and FLT-1.
Gene_expression (expression) of FLT-1
8) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.43 Pain Relevance 0
In contrast to our finding, increased expression of Flt-1 in the 6-month STZ-induced diabetic rat retinas was reported by Hammes et al. (31).
Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
9) Confidence 0.71 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.54 Pain Relevance 0
To detect VEGF-A, FLT-1, or FLK-1 antigen, the chest cavity was opened following anesthesia as described above.
Gene_expression (detect) of FLT-1 in cavity associated with anesthesia
10) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.13 Pain Relevance 0.23
No significant difference was detected in the expression of VEGF-A and its receptors (FLK-1 and FLT-1) between IVTA-treated and sham-treated nondiabetic retinas (PVEGF-A = 0.2641, PFLK-1 = 0.4792, and PFLT-1 = 0.5222) (Fig. 2A–C).


Gene_expression (expression) of FLT-1 in retinas
11) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.74 Pain Relevance 0
Intravitreal injection of TA stabilizes the BRB in association with regulation of Vegf-a, Flk-1, and Flt-1 expression in retinas in the early stages of diabetes.



Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
12) Confidence 0.55 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2836241 Disease Relevance 0.60 Pain Relevance 0
In contrast to the elevated levels of VEGF and FLK-1, FLT-1 expression was reduced by 37.5% in diabetic retinas (16.94 ± 0.76 vs. 27.09 ± 0.56 positive cells/mm, P < 0.0001) (Fig. 2C).
Gene_expression (expression) of FLT-1 in retinas associated with diabetes mellitus
13) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.87 Pain Relevance 0
Standard indirect immunohistochemical methods were used to detect leakage of albumin and the expression of VEGF-A, FLK-1, and FlT-1 (21).
Gene_expression (expression) of FlT-1
14) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0 Pain Relevance 0
TA downregulated the expression of Vegf-a and Flk-1 but upregulated the expression of Flt-1.
Gene_expression (expression) of Flt-1
15) Confidence 0.55 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2836241 Disease Relevance 0.61 Pain Relevance 0
Immunohistochemical quantification confirmed the decrease in VEGF and Flt1 protein expression and found a lack of change in Flk1 protein content.
Gene_expression (expression) of Flt1 protein
16) Confidence 0.52 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.77 Pain Relevance 0
The decrease in Flt1 expression seen in the presence of GLA may reduce the degree of protection of VEGF from degradation in the ECM thereby compounding the effect of decreased VEGF expression.
Gene_expression (expression) of Flt1 in ECM
17) Confidence 0.52 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.44 Pain Relevance 0
From the present study it may be suggested that the marked reduction in Flt1 and VEGF expression caused by GLA treatment could cause a reduction in angiogenesis as seen by reduced MVD most likely through reduced endothelial cell proliferation, although this was not quantified directly.
Gene_expression (expression) of Flt1 in endothelial cell
18) Confidence 0.52 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.55 Pain Relevance 0
The decrease in ERK1 and ERK2 expression may be involved in the decrease in VEGF and Flt1 expression in the GLA treated tumours.
Gene_expression (expression) of Flt1 associated with cancer
19) Confidence 0.52 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.67 Pain Relevance 0
The presence of GLA caused inhibition of mRNA expression of VEGF, Flt1, ERK1/2 and MMP2 but not Flk1.
Gene_expression (expression) of Flt1
20) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.79 Pain Relevance 0

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