INT100375

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 22.30
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) transcription factor binding (Vhl) cytoplasm (Vhl)
Anatomy Link Frequency
endothelial cells 2
central nervous system 1
Vhl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 9 99.64 Very High Very High Very High
Sciatica 1 98.96 Very High Very High Very High
cINOD 16 97.66 Very High Very High Very High
dexamethasone 1 94.36 High High
Pain 9 89.40 High High
imagery 13 78.96 Quite High
Spinal cord 1 71.88 Quite High
addiction 9 35.44 Quite Low
palliative 3 33.76 Quite Low
ischemia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 1296 100.00 Very High Very High Very High
Syndrome 653 100.00 Very High Very High Very High
Von Hippel-lindau Syndrome 46 100.00 Very High Very High Very High
Leiomyomatosis 45 100.00 Very High Very High Very High
Cancer 674 99.92 Very High Very High Very High
Disease 100 99.54 Very High Very High Very High
Nerve Root Compression 1 98.96 Very High Very High Very High
Carcinoma 91 98.76 Very High Very High Very High
Recurrence 61 98.48 Very High Very High Very High
Hypoxia 26 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
partial nephrectomy in patients with Von Hippel Lindau (VHL) syndrome
Gene_expression (syndrome) of VHL associated with syndrome and von hippel-lindau syndrome
1) Confidence 0.15 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2522334 Disease Relevance 2.20 Pain Relevance 0
Taken together, these results indicate that NSAIDs inhibit hypoxia-induced angiogenesis in endothelial cells by inhibiting VEGF and Flt-1 expression through increased VHL expression and the resulting ubiquitination and degradation of HIF-1alpha.
Gene_expression (expression) of VHL in endothelial cells associated with hypoxia and cinod
2) Confidence 0.11 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.88 Pain Relevance 0.61
The VHL gene
Gene_expression (gene) of VHL
3) Confidence 0.11 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.02 Pain Relevance 0.03
Each

inherited cancer syndrome, such as VHL, HPRC and hereditary leiomyomatosis and

Gene_expression (leiomyomatosis) of VHL associated with leiomyomatosis, syndrome, cancer and renal cancer
4) Confidence 0.11 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 3.30 Pain Relevance 0.03
encodes pVHL, which is part of a complex (including elongin B/C and CUL2) that
Gene_expression (including) of pVHL
5) Confidence 0.11 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.06 Pain Relevance 0.03
Here we demonstrate that both nonselective (indomethacin) and COX-2-selective (NS-398) NSAIDs inhibit hypoxia-induced in vitro angiogenesis in gastric microvascular endothelial cells via coordinated sequential events: 1) increased expression of the von Hippel-Lindau (VHL) tumor suppressor, which targets proteins for ubiquitination leading to 2) reduced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and, as a result, 3) reduced expression of vascular endothelial growth factor (VEGF) and its specific receptor Flt-1.
Gene_expression (expression) of VHL in endothelial cells associated with cancer, hypoxia and cinod
6) Confidence 0.10 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.90 Pain Relevance 0.52
Extrarenal manifestations of VHL include central nervous system
Gene_expression (manifestations) of VHL in central nervous system associated with central nervous system
7) Confidence 0.09 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.96 Pain Relevance 0.08
As renal tumors in VHL tend to be
Gene_expression (tumors) of VHL associated with renal cancer
8) Confidence 0.09 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.61 Pain Relevance 0.07
in VHL, HPRC, and BHD twins are often
Gene_expression (twins) of VHL associated with syndrome and renal cancer
9) Confidence 0.09 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.38 Pain Relevance 0.09
families with VHL syndrome frequently develop clear cell RCCs, whereas patients
Gene_expression (syndrome) of VHL associated with syndrome and carcinoma
10) Confidence 0.09 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.92 Pain Relevance 0.04
Five

deaths ocurred in both groups; three in the VHL group were due to metastatic

Gene_expression (group) of VHL
11) Confidence 0.09 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 0.88 Pain Relevance 0
VHL, HPRC, or BHD who presented with tumors less than 3 cm have had metastatic
Gene_expression (presented) of VHL associated with cancer, syndrome and renal cancer
12) Confidence 0.09 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.00 Pain Relevance 0
As the main problem in VHL is uncontrolled angiogenesis by overexpressing VEGF and VEGF receptors, Thalidomide (400 mg, later 600 mg) was added.
Gene_expression (overexpressing) of VHL
13) Confidence 0.09 Published 2007 Journal J Neurooncol Section Body Doc Link PMC1915654 Disease Relevance 1.11 Pain Relevance 0.18
Subsequently it was shown that sporadic ccRCC has biallelic deletion, mutation, or methylation of the VHL gene, and this feature has a major role in the pathogenesis of the disease.16 Loss of the normal VHL gene product in ccRCC results in constitutional high expression of the hypoxia response gene HIF-1?
Gene_expression (product) of VHL associated with hypoxia and disease
14) Confidence 0.05 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 1.07 Pain Relevance 0

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