INT100379

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 69
Total Number 69
Disease Relevance 57.31
Pain Relevance 10.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
epithelial cells 2
SK-MEL-28 1
muscles 1
nucleus 1
fibroblasts 1
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 198 100.00 Very High Very High Very High
aspirin 12 99.82 Very High Very High Very High
rheumatoid arthritis 481 99.74 Very High Very High Very High
opioid receptor 4 99.66 Very High Very High Very High
Inflammation 750 99.48 Very High Very High Very High
Pain 58 99.38 Very High Very High Very High
agonist 120 99.26 Very High Very High Very High
fortral 10 99.16 Very High Very High Very High
Dismenorea 8 99.14 Very High Very High Very High
cINOD 34 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 1204 100.00 Very High Very High Very High
Cv Unclassified Under Development 178 100.00 Very High Very High Very High
Neurodegenerative Disease 2 100.00 Very High Very High Very High
Stomach Cancer 10 99.96 Very High Very High Very High
Pancreatic Cancer 338 99.84 Very High Very High Very High
Cancer 1915 99.74 Very High Very High Very High
Rheumatoid Arthritis 481 99.74 Very High Very High Very High
Death 93 99.60 Very High Very High Very High
Aggression 5 99.54 Very High Very High Very High
INFLAMMATION 772 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the selective agonists of opioid receptors tested affected HIF-1 activation by hypoxia.
Positive_regulation (activation) of HIF-1 associated with hypoxia, agonist and opioid receptor
1) Confidence 0.69 Published 2005 Journal J Anesth Section Abstract Doc Link 16032459 Disease Relevance 0.45 Pain Relevance 0.54
Here we demonstrate that both nonselective (indomethacin) and COX-2-selective (NS-398) NSAIDs inhibit hypoxia-induced in vitro angiogenesis in gastric microvascular endothelial cells via coordinated sequential events: 1) increased expression of the von Hippel-Lindau (VHL) tumor suppressor, which targets proteins for ubiquitination leading to 2) reduced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and, as a result, 3) reduced expression of vascular endothelial growth factor (VEGF) and its specific receptor Flt-1.
Positive_regulation (accumulation) of HIF-1alpha in endothelial cells associated with cancer, hypoxia and cinod
2) Confidence 0.67 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.98 Pain Relevance 0.54
Compared to women without the disease, VEGF expression was increased in endometrium with a normal location in patients with adenomyosis, although not associated to a significant increase of HIF-1alpha and MVD.
Positive_regulation (increase) of HIF-1alpha in endometrium associated with dismenorea and disease
3) Confidence 0.67 Published 2009 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 19188818 Disease Relevance 1.08 Pain Relevance 0.58
HIF-1alpha accumulation was evaluated by Western blotting and immunofluorescence.
Positive_regulation (accumulation) of HIF-1alpha
4) Confidence 0.67 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.17 Pain Relevance 0
HIF-1alpha, which is clearly activated in response to hypoxia, may control the expression of VEGF in synovial fibroblasts from TMJ.


Positive_regulation (activated) of HIF-1alpha in fibroblasts
5) Confidence 0.67 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.13 Pain Relevance 0
Combining the sigma-1 agonist (+)-pentazocine with rimcazole substantially reduces the accumulation of HIF-1alpha, confirming that the effect is mediated at least partly by antagonism of sigma-1 sites.
Positive_regulation (accumulation) of HIF-1alpha associated with fortral and agonist
6) Confidence 0.67 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.61 Pain Relevance 0.19
Thus, the induction of HIF-1alpha by rimcazole contributes to tumour cell killing.
Positive_regulation (induction) of HIF-1alpha associated with cancer
7) Confidence 0.67 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.65 Pain Relevance 0.17
We now report that rimcazole elevates hypoxia inducible factor-1alpha (HIF-1alpha) protein levels under normoxic conditions in colorectal (HCT-116) and mammary carcinoma (MDA MB 231) cells but fails to induce HIF-1alpha in normal fibroblasts or mammary epithelial cells.
Positive_regulation (elevates) of HIF-1alpha in epithelial cells associated with hypoxia and carcinoma
8) Confidence 0.67 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.49 Pain Relevance 0.16
We now report that rimcazole elevates hypoxia inducible factor-1alpha (HIF-1alpha) protein levels under normoxic conditions in colorectal (HCT-116) and mammary carcinoma (MDA MB 231) cells but fails to induce HIF-1alpha in normal fibroblasts or mammary epithelial cells.
Neg (fails) Positive_regulation (induce) of HIF-1alpha in epithelial cells associated with hypoxia and carcinoma
9) Confidence 0.67 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.50 Pain Relevance 0.18
This suggests that the presence of functional p53 protein may enhance death induction by rimcazole in part through greater induction of HIF-1alpha. p53 is not required, however, for the rimcazole-induced engagement of HIF-1alpha in proapoptotic mode as HIF-1alpha knockdown attenuates rimcazole-induced death to comparable extents in p53 mutant and wild-type cell systems.
Positive_regulation (induction) of HIF-1alpha associated with death
10) Confidence 0.67 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.70 Pain Relevance 0.14
The increase in HIF-1?
Positive_regulation (increase) of HIF
11) Confidence 0.67 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.65 Pain Relevance 0.12
Briefly, hypoxia stabilizes alfa subunit of HIF-1, which enters the nucleus in a dimerized form and results in the induction of HIF target genes.
Positive_regulation (induction) of HIF in nucleus associated with hypoxia
12) Confidence 0.67 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.92 Pain Relevance 0.55
Further, an electrophoretic mobility shift assay (EMSA) from nuclear extracts from melanoma cells showed a decrease in constitutive activation of NF-kappaB and enhanced HIF-1alpha binding activity to hypoxia response element (HRE) in melanoma cells treated with different concentrations of capsaicin.
Positive_regulation (enhanced) of HIF-1alpha
13) Confidence 0.67 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.08 Pain Relevance 0
Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation.
Positive_regulation (upregulated) of HIF-1alpha
14) Confidence 0.67 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 18924134 Disease Relevance 1.17 Pain Relevance 0.30
To delineate the mechanisms involved we investigate the role of hypoxia inducible factor 1 alpha (HIF-1 alpha), a potent inducer of angiogenic growth factor.
Positive_regulation (inducer) of HIF-1 alpha associated with hypoxia
15) Confidence 0.49 Published 2010 Journal Cell. Immunol. Section Abstract Doc Link 20843508 Disease Relevance 0.57 Pain Relevance 0.71
To delineate the mechanisms involved we investigate the role of hypoxia inducible factor 1 alpha (HIF-1 alpha), a potent inducer of angiogenic growth factor.
Positive_regulation (inducible) of HIF-1 alpha associated with hypoxia
16) Confidence 0.49 Published 2010 Journal Cell. Immunol. Section Abstract Doc Link 20843508 Disease Relevance 0.57 Pain Relevance 0.70
Aspirin induced HIF-1alpha stabilization and TFF2 mRNA up-regulation in the mucosa, but these effects were diminished when iNOS activity was inhibited.
Positive_regulation (stabilization) of HIF-1alpha associated with aspirin
17) Confidence 0.49 Published 2010 Journal FASEB J. Section Abstract Doc Link 19741170 Disease Relevance 0.24 Pain Relevance 0.20
Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation.
Positive_regulation (upregulated) of HIF-1alpha
18) Confidence 0.49 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 18924134 Disease Relevance 1.17 Pain Relevance 0.30
Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor induced by hypoxic condition, plays a major role in the pleiotropic response observed under hypoxic conditions.
Positive_regulation (induced) of HIF-1 associated with hypoxia
19) Confidence 0.49 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.71 Pain Relevance 0
Studies have shown reactive oxygen species from Helicobacter pylori, associated with the development of gastric cancer, stabilise HIF-1alpha.
Positive_regulation (stabilise) of HIF-1alpha associated with ulcers and stomach cancer
20) Confidence 0.49 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.38 Pain Relevance 0.10

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