INT100380

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
endothelial cells 2
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fortral 2 99.40 Very High Very High Very High
agonist 1 99.08 Very High Very High Very High
cINOD 8 94.92 High High
antagonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 8 100.00 Very High Very High Very High
Cancer 7 98.62 Very High Very High Very High
Carcinoma 1 92.92 High High
Death 3 86.88 High High
Ulcers 1 80.92 Quite High
INFLAMMATION 1 77.28 Quite High
Apoptosis 1 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that both nonselective (indomethacin) and COX-2-selective (NS-398) NSAIDs inhibit hypoxia-induced in vitro angiogenesis in gastric microvascular endothelial cells via coordinated sequential events: 1) increased expression of the von Hippel-Lindau (VHL) tumor suppressor, which targets proteins for ubiquitination leading to 2) reduced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and, as a result, 3) reduced expression of vascular endothelial growth factor (VEGF) and its specific receptor Flt-1.
Negative_regulation (reduced) of Positive_regulation (accumulation) of HIF-1alpha in endothelial cells associated with cancer, hypoxia and cinod
1) Confidence 0.57 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.98 Pain Relevance 0.54
Combining the sigma-1 agonist (+)-pentazocine with rimcazole substantially reduces the accumulation of HIF-1alpha, confirming that the effect is mediated at least partly by antagonism of sigma-1 sites.
Negative_regulation (reduces) of Positive_regulation (accumulation) of HIF-1alpha associated with fortral and agonist
2) Confidence 0.42 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.62 Pain Relevance 0.19

General Comments

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