INT100381

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 12.05
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
endothelial cells 2
nucleus 2
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 97.60 Very High Very High Very High
Inflammation 42 96.20 Very High Very High Very High
cINOD 15 95.20 Very High Very High Very High
ischemia 131 94.64 High High
fortral 2 89.28 High High
agonist 17 88.64 High High
Opioid 2 87.28 High High
Central nervous system 3 83.68 Quite High
Chronic pancreatitis 6 77.88 Quite High
Kinase C 16 77.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 664 100.00 Very High Very High Very High
Hypoxia 236 100.00 Very High Very High Very High
Aggression 2 100.00 Very High Very High Very High
Pancreatic Cancer 174 99.76 Very High Very High Very High
Death 21 98.76 Very High Very High Very High
Renal Cancer 2 97.56 Very High Very High Very High
INFLAMMATION 44 96.20 Very High Very High Very High
Solid Tumor 19 95.08 Very High Very High Very High
Cv Unclassified Under Development 121 94.64 High High
Ovarian Cancer 28 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that both nonselective (indomethacin) and COX-2-selective (NS-398) NSAIDs inhibit hypoxia-induced in vitro angiogenesis in gastric microvascular endothelial cells via coordinated sequential events: 1) increased expression of the von Hippel-Lindau (VHL) tumor suppressor, which targets proteins for ubiquitination leading to 2) reduced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and, as a result, 3) reduced expression of vascular endothelial growth factor (VEGF) and its specific receptor Flt-1.
Positive_regulation (leading) of Positive_regulation (accumulation) of HIF-1alpha in endothelial cells associated with cancer, hypoxia and cinod
1) Confidence 0.49 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.98 Pain Relevance 0.54
To delineate the mechanisms involved we investigate the role of hypoxia inducible factor 1 alpha (HIF-1 alpha), a potent inducer of angiogenic growth factor.
Positive_regulation (inducible) of Positive_regulation (inducer) of HIF-1 alpha associated with hypoxia
2) Confidence 0.49 Published 2010 Journal Cell. Immunol. Section Abstract Doc Link 20843508 Disease Relevance 0.57 Pain Relevance 0.71
Thus, the induction of HIF-1alpha by rimcazole contributes to tumour cell killing.
Positive_regulation (contributes) of Positive_regulation (induction) of HIF-1alpha associated with cancer
3) Confidence 0.45 Published 2007 Journal Oncogene Section Abstract Doc Link 16924239 Disease Relevance 0.71 Pain Relevance 0.17
Briefly, hypoxia stabilizes alfa subunit of HIF-1, which enters the nucleus in a dimerized form and results in the induction of HIF target genes.
Positive_regulation (results) of Positive_regulation (induction) of HIF in nucleus associated with hypoxia
4) Confidence 0.45 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.92 Pain Relevance 0.55
Thus, loss of the VHL protein results in constitutive stabilization of HIF-1?
Positive_regulation (results) of Positive_regulation (stabilization) of HIF-1
5) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.65 Pain Relevance 0.04
In vitro all pancreatic cancer cell lines increased VEGF production under low oxygen levels by highly specific activation of HIF-1 DNA binding activity to the VEGF promotor [43].
Positive_regulation (increased) of Positive_regulation (activation) of HIF-1 associated with pancreatic cancer
6) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.49 Pain Relevance 0.08
This condition, termed pseudohypoxia, can increase aggressiveness of tumors through the induction of HIF1 target genes such as VEGF or lysl oxidase.
Positive_regulation (increase) of Positive_regulation (induction) of HIF1 associated with cancer and aggression
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 1.25 Pain Relevance 0
The mechanism by which they can suppress tumorgenicity has yet to be fully determined, but it has been shown that these mutations cause a buildup of TCA intermediates that can lead to stabilization of the HIF1 transcription factor [21].
Positive_regulation (lead) of Positive_regulation (stabilization) of HIF1
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 1.06 Pain Relevance 0
Cytoskeletal remodeling, WNT signaling, FAK signaling, hypoxia-induced HIF1 activation, and insulin regulation were identified as being among the most important biological pathways involved in transformation.


Positive_regulation (induced) of Positive_regulation (activation) of HIF1 associated with hypoxia
9) Confidence 0.15 Published 2010 Journal BMC Syst Biol Section Abstract Doc Link PMC2958164 Disease Relevance 0.17 Pain Relevance 0
cancer (RCC) leading to constitutive activation of hypoxia-inducible factor-1

(HIF-1) target genes.

Positive_regulation (leading) of Positive_regulation (activation) of hypoxia-inducible factor-1 associated with hypoxia and cancer
10) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.69 Pain Relevance 0
The HIF response is mediated through the transcription factor dimer inducible HIF-1?
Positive_regulation (mediated) of Positive_regulation (inducible) of HIF-1
11) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.88 Pain Relevance 0
Therefore, ET-1-induced HIF-1 accumulation activates all the signals necessary for a complete HIF-1 response [19].
Positive_regulation (activates) of Positive_regulation (accumulation) of HIF-1
12) Confidence 0.09 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.97 Pain Relevance 0.07
The same agent may also stimulate angiogenesis via the induction of heme oxygenase-1 (HO-1), endothelial nitric-oxide synthase, and hypoxia-inducible factor-1a (HIF-1) [48].
Spec (may) Positive_regulation (stimulate) of Positive_regulation (induction) of HIF-1 associated with hypoxia
13) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.69 Pain Relevance 0

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