INT100382

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.75
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
endothelial cells 2
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 98.64 Very High Very High Very High
Inflammatory response 2 61.44 Quite High
agonist 43 50.00 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 150 98.60 Very High Very High Very High
Hypoxia 12 97.52 Very High Very High Very High
INFLAMMATION 28 61.44 Quite High
Acute-phase Reaction 1 58.56 Quite High
Ulcers 1 53.68 Quite High
Hematologic Neoplasms 39 50.00 Quite Low
Metastasis 14 38.80 Quite Low
Advanced Or Metastatic Breast Cancer 3 27.00 Quite Low
Colon Cancer 4 25.84 Quite Low
Solid Tumor 8 18.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that NSAIDs inhibit hypoxia-induced angiogenesis in endothelial cells by inhibiting VEGF and Flt-1 expression through increased VHL expression and the resulting ubiquitination and degradation of HIF-1alpha.
Positive_regulation (resulting) of Protein_catabolism (degradation) of HIF-1alpha in endothelial cells associated with hypoxia and cinod
1) Confidence 0.45 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.87 Pain Relevance 0.61
for the tumor suppressor protein von Hippel-Lindau (pVHL) E3 ligase complex, which mediates ubiquitination and proteasomal degradation of HIF-1?
Positive_regulation (mediates) of Protein_catabolism (degradation) of HIF-1 associated with cancer
2) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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