INT100394

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 9.24
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trp53bp2) cell cycle (Trp53bp2) cytoplasm (Trp53bp2)
Anatomy Link Frequency
pancreas 2
puncture 1
Trp53bp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 100.00 Very High Very High Very High
Chronic pancreatitis 27 99.52 Very High Very High Very High
nud 1 67.76 Quite High
backache 1 66.72 Quite High
vincristine 1 55.44 Quite High
chemokine 5 9.52 Low Low
tolerance 9 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 109 99.84 Very High Very High Very High
Nicotine Addiction 42 99.84 Very High Very High Very High
Pancreatitis 32 99.52 Very High Very High Very High
Pancreatic Cancer 14 97.60 Very High Very High Very High
Adenocarcinoma 1 91.76 High High
Carcinoma 4 90.72 High High
Hepatocellular Cancer 4 84.52 Quite High
Disease 4 79.64 Quite High
Pathologic Constriction 1 79.48 Quite High
Sarcoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical examination showed that the p53 protein and the alpha5beta1-integrin were expressed in tumour cells, and the proliferating cell nuclear antigen test was positive.
Gene_expression (expressed) of p53 protein associated with cancer
1) Confidence 0.65 Published 2004 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15028977 Disease Relevance 0.68 Pain Relevance 0.09
AIM: To evaluate p53 protein overexpression and to measure serum CA19.9 concentrations in cytological diagnosis of patients with suspected pancreatic cancer.
Gene_expression (overexpression) of p53 protein associated with pancreatic cancer
2) Confidence 0.42 Published 2003 Journal World J. Gastroenterol. Section Abstract Doc Link 12918127 Disease Relevance 0.32 Pain Relevance 0.15
p53 protein expression and CA19.9 values in differential cytological diagnosis of pancreatic cancer complicated with chronic pancreatitis and chronic pancreatitis.
Gene_expression (expression) of p53 protein associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.42 Published 2003 Journal World J. Gastroenterol. Section Title Doc Link 12918127 Disease Relevance 0.29 Pain Relevance 0.19
On laparotomy, puncture biopsy was performed, and specimens were divided into two parts for cytological diagnosis and detection of p53 protein.
Gene_expression (detection) of p53 protein in puncture
4) Confidence 0.33 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 12918127 Disease Relevance 0.09 Pain Relevance 0
Cigarette smoking increases the expression p53 protein in pancreas of smoking patients with chronic pancreatitis.
Gene_expression (expression) of p53 protein in pancreas associated with nicotine addiction and chronic pancreatitis
5) Confidence 0.15 Published 2006 Journal Prz. Lek. Section Abstract Doc Link 17288189 Disease Relevance 1.55 Pain Relevance 0.46
The study revealed a expression of p53 protein in smoking CP patients.
Gene_expression (expression) of p53 protein associated with nicotine addiction and chronic pancreatitis
6) Confidence 0.15 Published 2006 Journal Prz. Lek. Section Abstract Doc Link 17288189 Disease Relevance 1.62 Pain Relevance 0.48
Smoking patients above the twenty cigarettes for day showed significantly higher expression of p53 protein in the pancreas compared to smoking patients less.
Gene_expression (expression) of p53 protein in pancreas associated with nicotine addiction
7) Confidence 0.15 Published 2006 Journal Prz. Lek. Section Abstract Doc Link 17288189 Disease Relevance 1.59 Pain Relevance 0.47
Of the 11 cases that were positive for anti-53 antibodies, 8 (73%) were also positive for the immunohistochemical expression of p53 protein in cancer cells.
Gene_expression (expression) of p53 protein associated with cancer
8) Confidence 0.10 Published 2002 Journal Int J Gastrointest Cancer Section Abstract Doc Link 12622424 Disease Relevance 0.87 Pain Relevance 0.08
However, there was no significant correlation between the presence of anti-p53 antibodies and the serum p53 protein levels.
Gene_expression (presence) of p53 protein
9) Confidence 0.09 Published 2002 Journal Int J Gastrointest Cancer Section Abstract Doc Link 12622424 Disease Relevance 0.84 Pain Relevance 0.08
In contrast, knockdown of TLR2 significantly reversed the effects of Pam3Cys on the expressions of the pro-metastatic proteins, suppressive cytokines and p53 protein (Fig.
Gene_expression (expressions) of p53 protein associated with cytokine
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.11 Pain Relevance 0.05
All 279 specimens of resected tumors were submitted to the following assessments: PCNA and expression of P53 protein.
Gene_expression (expression) of P53 protein
11) Confidence 0.02 Published 2000 Journal Chin. Med. J. Section Body Doc Link 11776102 Disease Relevance 0.08 Pain Relevance 0
There was no statistical difference in expression of P53 protein between the TACE and control group.
Gene_expression (expression) of P53 protein
12) Confidence 0.02 Published 2000 Journal Chin. Med. J. Section Body Doc Link 11776102 Disease Relevance 0.05 Pain Relevance 0
In addition, p53 protein was expressed in 40% of tumor cells, and Ki-67 was demonstrated in 45% of tumor cells.
Gene_expression (expressed) of p53 protein associated with cancer
13) Confidence 0.01 Published 2002 Journal Chang Gung Med J Section Abstract Doc Link 12173670 Disease Relevance 1.14 Pain Relevance 0.13

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