INT100396

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.48
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
trigeminal ganglion 1
eye 1
aorta 1
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
pulpitis 6 100.00 Very High Very High Very High
trigeminal ganglion 5 99.44 Very High Very High Very High
fifth nerve 2 83.32 Quite High
anesthesia 4 77.56 Quite High
Snapping jaw 3 56.40 Quite High
medulla 19 51.04 Quite High
agonist 1 46.48 Quite Low
antagonist 2 35.12 Quite Low
Pain 1 25.00 Low Low
corticosteroid 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulpitis 6 100.00 Very High Very High Very High
Nociception 4 99.12 Very High Very High Very High
Ganglion Cysts 5 99.00 Very High Very High Very High
Diabetes Mellitus 137 98.56 Very High Very High Very High
Hyperglycemia 8 94.24 High High
Renal Disease 8 64.36 Quite High
Temporomandibular Joint Syndrome 3 56.40 Quite High
Disease 2 54.88 Quite High
Diabetic Retinopathy 1 53.88 Quite High
Hyperalgesia 1 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To study the relationship between endothelin-1(ET-1) and inducible nitric oxide synthase (iNOS) through the mRNA expression in pulpitis.
Transcription (expression) of endothelin-1 associated with pulpitis
1) Confidence 0.69 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Abstract Doc Link 11776875 Disease Relevance 0.17 Pain Relevance 0.17
RESULTS: The mRNA expression of ET-1/iNOS in pulpitis groups was higher than the control.
Transcription (expression) of ET-1
2) Confidence 0.69 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 11776875 Disease Relevance 0.09 Pain Relevance 0
As a result, the expressions of ETA and ETB receptors are reduced with both immunostaining and the mRNA levels in the left eye, in which endothelin-1 eyedrops were applied at 4 x 10(-5) M.
Transcription (applied) of endothelin-1 in eye
3) Confidence 0.65 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838338 Disease Relevance 0.16 Pain Relevance 0.08
There was relationship in the mRNA expression between ET-1 and iNOS.
Transcription (expression) of ET-1
4) Confidence 0.51 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 11776875 Disease Relevance 0.09 Pain Relevance 0
Herein ET-1 and ET-3 mRNA was detected in the rats' trigeminal ganglion (TG).
Transcription (detected) of ET-1 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
5) Confidence 0.47 Published 2010 Journal Brain Res. Section Abstract Doc Link 20450894 Disease Relevance 0.87 Pain Relevance 0.38
The equations describing ET-1 mRNA (mRNA) time profile following MPL treatment are:
Transcription (profile) of ET-1 mRNA
6) Confidence 0.46 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Makino et al. [27] demonstrated upregulated preproET-1 mRNA in the aorta from STZ-induced diabetic rats.
Transcription (demonstrated) of preproET-1 in aorta associated with diabetes mellitus
7) Confidence 0.46 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.09 Pain Relevance 0.03

General Comments

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