INT100398

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.26
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL17) extracellular region (CCL17) cell-cell signaling (CCL17)
Anatomy Link Frequency
1C6 4
skin 4
monocytes 2
epithelium 2
CCL17 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 51 100.00 Very High Very High Very High
Inflammation 42 94.72 High High
corticosteroid 4 85.12 High High
Inflammatory mediators 1 84.92 Quite High
cytokine 30 83.84 Quite High
lidocaine 5 54.24 Quite High
anesthesia 5 53.48 Quite High
Inflammatory marker 8 50.00 Quite Low
rheumatoid arthritis 12 46.24 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 51 94.72 High High
Contact Dermatitis 112 89.64 High High
Necrosis 1 85.88 High High
Cancer 3 85.52 High High
Hypersensitivity 47 85.44 High High
Respiratory Disease 1 84.72 Quite High
Disease 23 79.72 Quite High
Syndrome 28 78.16 Quite High
Apoptosis 4 75.52 Quite High
Rhinitis 1 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Positive_regulation (elevated) of Gene_expression (expression) of TARC in skin associated with inflammation
1) Confidence 0.53 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
It is considered that the regenerated epithelium after TCA treatment originates from the glandular epithelium with negative TARC expression existing in the area deeper than a 120-microm level and that this immunohistological change would lead to the effectiveness of TCA treatment.
Positive_regulation (negative) of Gene_expression (expression) of TARC in epithelium associated with chemokine
2) Confidence 0.50 Published 2001 Journal Am J Rhinol Section Abstract Doc Link 11777248 Disease Relevance 0.13 Pain Relevance 0.40
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Positive_regulation (elevated) of Gene_expression (expression) of CCL17 in skin associated with inflammation
3) Confidence 0.38 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Positive_regulation (incubated) of Gene_expression (one) of TARC in 1C6
4) Confidence 0.38 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Positive_regulation (incubated) of Gene_expression (one) of CCL17 in 1C6
5) Confidence 0.38 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
Interestingly, high levels of expression of SCYA17 were observed in lipopolysaccharide-stimulated human monocytes [21].
Positive_regulation (levels) of Gene_expression (expression) of SCYA17 in monocytes
6) Confidence 0.33 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.66 Pain Relevance 0.18

General Comments

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