INT100399

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 9.38
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL17) extracellular region (CCL17) cell-cell signaling (CCL17)
Anatomy Link Frequency
skin 7
1C6 4
epithelium 1
eosinophils 1
endothelial cells 1
CCL17 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 174 100.00 Very High Very High Very High
Inflammation 158 94.72 High High
cytokine 109 85.16 High High
corticosteroid 17 84.76 Quite High
Inflammatory mediators 4 84.52 Quite High
rheumatoid arthritis 43 82.64 Quite High
Inflammatory marker 28 75.00 Quite High
lidocaine 15 53.88 Quite High
anesthesia 15 53.12 Quite High
tolerance 3 41.44 Quite Low
Disease Link Frequency Relevance Heat
Eosinophilia 2 99.08 Very High Very High Very High
Respiratory Disease 4 98.80 Very High Very High Very High
Hypersensitivity 160 98.68 Very High Very High Very High
T-cell Lymphoma 21 98.44 Very High Very High Very High
Contact Dermatitis 392 98.20 Very High Very High Very High
Adhesions 66 96.40 Very High Very High Very High
Osteomyelitis 22 95.68 Very High Very High Very High
INFLAMMATION 190 94.72 High High
Cancer 56 94.16 High High
Dermatitis 56 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is considered that the regenerated epithelium after TCA treatment originates from the glandular epithelium with negative TARC expression existing in the area deeper than a 120-microm level and that this immunohistological change would lead to the effectiveness of TCA treatment.
Gene_expression (expression) of TARC in epithelium associated with chemokine
1) Confidence 0.77 Published 2001 Journal Am J Rhinol Section Abstract Doc Link 11777248 Disease Relevance 0.13 Pain Relevance 0.40
The number of mononuclear cells expressing a particular antigen were informed per mm2, whereas the expression of CS-1 fibronectin and CCL17 on blood vessels was measured using the following criteria (negative, low = less than 40% of blood vessels, intermediate = between 40 and 70 % of blood vessels, and high = more than 70% of blood vessels).


Gene_expression (expression) of CCL17 in blood vessels
2) Confidence 0.59 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.07
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Gene_expression (expression) of TARC in skin associated with inflammation
3) Confidence 0.59 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
In addition to the expression of E-selectin, CCL17, CXCL16, CX3CL1, and increased numbers of integrin ligands [33-35], we show here for the first time a very early production of CS-1 fibronectin by activated endothelial cells in patients with ACD.
Gene_expression (expression) of CCL17 in endothelial cells associated with contact dermatitis
4) Confidence 0.59 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.09 Pain Relevance 0
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Gene_expression (expression) of CCL17 in skin associated with inflammation
5) Confidence 0.59 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
Thus, inappropriate topical expression of SCYA17 could induce a localized immune or auto-immune response.
Gene_expression (expression) of SCYA17
6) Confidence 0.54 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.76 Pain Relevance 0.15
Interestingly, high levels of expression of SCYA17 were observed in lipopolysaccharide-stimulated human monocytes [21].
Gene_expression (expression) of SCYA17 in monocytes
7) Confidence 0.54 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.66 Pain Relevance 0.18
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Gene_expression (/) of TARC in 1C6
8) Confidence 0.52 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Gene_expression (/) of CCL17 in 1C6
9) Confidence 0.52 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Gene_expression (one) of TARC in 1C6
10) Confidence 0.52 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Gene_expression (one) of CCL17 in 1C6
11) Confidence 0.52 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
CES1 and MMP2 were mapped to clones in the BAC contigs (see additional data file 1, blau_map.pdf), whereas SCYA17 and the markers Cda1jb12 and R55777 were mapped to the BAC clones, CITB_387I12, CITB_437K19 and CITB_229H3, which map 1.1 Mbp telomeric to D16S408 according to the NCBI human genomic data (data not shown).
Gene_expression (mapped) of SCYA17
12) Confidence 0.47 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.49 Pain Relevance 0
By contrast, CCL17 expression was only seen after 10 hours in less than 40% of vessels and scattered keratinocytes throughout the epidermis.
Gene_expression (expression) of CCL17 in epidermis
13) Confidence 0.46 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.25 Pain Relevance 0
We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis and an irrelevant antigen.


Gene_expression (expression) of TARC in skin associated with chemokine and contact dermatitis
14) Confidence 0.46 Published 2002 Journal BMC Dermatol Section Abstract Doc Link PMC122084 Disease Relevance 0.55 Pain Relevance 0.14
We also report here that CCL17 is also produced by scattered keratinocytes in patients with ACD which since to be similar to the finding of Vestergaard C et al in skin biopsies from patients with atopic dermatitis [29].
Gene_expression (produced) of CCL17 in keratinocytes associated with dermatitis and contact dermatitis
15) Confidence 0.46 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 1.02 Pain Relevance 0.12
These results showed for the first time a very early expression of CS-1 fibronectin which preceded production of CCL17 in blood endothelial cells (BCEs) from patients' skin with ACD.
Gene_expression (production) of CCL17 in skin associated with contact dermatitis
16) Confidence 0.46 Published 2002 Journal BMC Dermatol Section Abstract Doc Link PMC122084 Disease Relevance 0.48 Pain Relevance 0.10
We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis and an irrelevant antigen.


Gene_expression (expression) of CCL17 in skin associated with chemokine and contact dermatitis
17) Confidence 0.46 Published 2002 Journal BMC Dermatol Section Abstract Doc Link PMC122084 Disease Relevance 0.55 Pain Relevance 0.14
Four genes, namely, CES1, MMP2, MMP15, and SCYA17, were selected based on their biochemical function and physical map locations prior to completion of our high-resolution map.
Gene_expression (selected) of SCYA17
18) Confidence 0.42 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0 Pain Relevance 0
We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis and an irrelevant antigen.


Gene_expression (expression) of activation-regulated chemokine in skin associated with chemokine and contact dermatitis
19) Confidence 0.40 Published 2002 Journal BMC Dermatol Section Abstract Doc Link PMC122084 Disease Relevance 0.55 Pain Relevance 0.14
The relevance of such interactions has been amply demonstrated in humans, where postcapillary venules in the inflamed skin selectively express E-selectin and CCL17, while lamina propria of the small intestines displays the mucosal addressin MAdCAM-1 and CCL25 [5-7].
Gene_expression (express) of CCL17 in venules
20) Confidence 0.32 Published 2006 Journal BMC Immunol Section Body Doc Link PMC1539023 Disease Relevance 0.16 Pain Relevance 0.04

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