INT1004

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 37
Speculated 21
Reported most in Abstract
Documents 140
Total Number 162
Disease Relevance 18.52
Pain Relevance 94.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
brain 9
neurons 8
stomach 5
spinal cord 4
plasma 4
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 935 100.00 Very High Very High Very High
substance P 148 100.00 Very High Very High Very High
Neuropeptide 117 100.00 Very High Very High Very High
Enkephalin 113 100.00 Very High Very High Very High
Cholecystokinin 86 100.00 Very High Very High Very High
Calcitonin gene-related peptide 68 100.00 Very High Very High Very High
qutenza 62 100.00 Very High Very High Very High
Morphine 60 100.00 Very High Very High Very High
tetrodotoxin 56 100.00 Very High Very High Very High
antagonist 41 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 33 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
Cancer Pain 1 100.00 Very High Very High Very High
Arthritis 19 99.98 Very High Very High Very High
Inflammatory Pain 3 99.64 Very High Very High Very High
Neuropathic Pain 10 99.18 Very High Very High Very High
Vibrio Infection 8 98.92 Very High Very High Very High
Glioma 2 98.70 Very High Very High Very High
Drug Induced Neurotoxicity 3 98.68 Very High Very High Very High
Spinal Injuries 2 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether biosynthesis of somatostatin is enhanced in the primary sensory neurons by inflammatory pain, we examined the effects of adjuvant inoculation on the content of immunoreactive somatostatin, mainly composed of somatostatin-14 and somatostatin-28, in the dorsal root ganglia and the spinal cord of the rat.
Spec (examined) Regulation (effects) of somatostatin in dorsal root ganglia associated with ipn, somatostatin and spinal cord
1) Confidence 0.62 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.33 Pain Relevance 0.76
[Effects of somatostatin and its analog on gastric secretion.
Regulation (Effects) of somatostatin associated with somatostatin
2) Confidence 0.62 Published 1985 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 2867956 Disease Relevance 0 Pain Relevance 0.20
Similarly we also demonstrated that perineural capsaicin treatment of the celiac-superior mesenteric ganglia did not affect the inhibitory action of somatostatin.
Neg (not) Regulation (affect) of somatostatin in ganglia associated with qutenza and somatostatin
3) Confidence 0.62 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8103634 Disease Relevance 0 Pain Relevance 0.55
A decrease in B-endorphin hypothalamic concentrations was also present in rats treated neonatally, while substance P, somatostatin and met-enkephalin concentrations were never affected by capsaicin treatment.
Regulation (affected) of somatostatin associated with qutenza, somatostatin, enkephalin and substance p
4) Confidence 0.62 Published 1983 Journal Pharmacol Res Commun Section Abstract Doc Link 6196795 Disease Relevance 0 Pain Relevance 0.63
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
Regulation (Effect) of somatostatin in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
5) Confidence 0.60 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.83
However, to date, the role of endogenous 5-hydroxytryptamine (serotonin) on the regulation of the somatostatin (SS) receptor-adenylyl cyclase (AC) system remains unclear.
Regulation (regulation) of somatostatin associated with somatostatin and serotonin
6) Confidence 0.60 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221908 Disease Relevance 0 Pain Relevance 0.43
The influence of somatostatin on postoperative outcome after elective pancreatic surgery.
Regulation (influence) of somatostatin associated with somatostatin
7) Confidence 0.60 Published 1998 Journal Acta Chir. Belg. Section Title Doc Link 9615159 Disease Relevance 0.16 Pain Relevance 0.29
In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin content of any of the medullary nuclei assayed while depleting the substance P content of the spinal trigeminal nucleus in the same animals.
Neg (no) Regulation (effect) of somatostatin in spinal trigeminal nucleus associated with qutenza, somatostatin and substance p
8) Confidence 0.60 Published 1983 Journal Peptides Section Abstract Doc Link 6197700 Disease Relevance 0 Pain Relevance 0.44
The somatostatin response to ANP was unaffected by the axonal blocker tetrodotoxin but abolished by addition of the selective NPR-A antagonist, anantin.
Neg (unaffected) Regulation (unaffected) of somatostatin associated with tetrodotoxin, antagonist and somatostatin
9) Confidence 0.59 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.16 Pain Relevance 0.58
Substance P had no effect on somatostatin mRNA in the gastric corpus in either control or capsaicin-treated rats.
Neg (no) Regulation (effect) of somatostatin mRNA in gastric corpus associated with qutenza, somatostatin and substance p
10) Confidence 0.58 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7521952 Disease Relevance 0 Pain Relevance 0.71
We studied the effects of somatostatin receptor modulation in the posterior hypothalamic area (PH) of the rat on dural nociceptive input.
Regulation (modulation) of somatostatin in posterior associated with nociception and somatostatin
11) Confidence 0.58 Published 2005 Journal Pain Section Abstract Doc Link 16043293 Disease Relevance 0.27 Pain Relevance 0.60
Mechanisms regulating the content of the putative peptide transmitters, substance P and somatostatin, were examined in several neuronal populations in culture.
Regulation (regulating) of somatostatin in neuronal associated with somatostatin and substance p
12) Confidence 0.54 Published 1983 Journal Neuroscience Section Abstract Doc Link 6192361 Disease Relevance 0.09 Pain Relevance 0.35
AIM: To study the interactive influence of somatostatin (Som) and GABA in the brain and its relation to the pain modulation.
Regulation (influence) of somatostatin in brain associated with pain, gaba and somatostatin
13) Confidence 0.49 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 7668103 Disease Relevance 0.17 Pain Relevance 0.46
Bicuculline (GABAA antagonist) inhibited L-[3H]citrulline, had no effect on somatostatin, and reversed Met-enkephalin from decrease below to increase above basal level; exogenous GABA had the opposite effect.
Neg (no) Regulation (effect) of somatostatin associated with gaba, antagonist, somatostatin and enkephalin
14) Confidence 0.46 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943334 Disease Relevance 0 Pain Relevance 1.41
Naloxone increased GABA and L-[3H]citrulline but had no effect on somatostatin; exogenous Met-enkephalin had the opposite effect.
Neg (no) Regulation (effect) of somatostatin associated with gaba, somatostatin, narcan and enkephalin
15) Confidence 0.46 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943334 Disease Relevance 0 Pain Relevance 1.66
A combination of atropine and the bombesin/GRP antagonist, like TTX, abolished the gastrin and somatostatin responses.
Regulation (responses) of somatostatin associated with tetrodotoxin, antagonist and somatostatin
16) Confidence 0.46 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.68
The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord.
Regulation (effects) of somatostatin in dorsal horn associated with nociception, pain, dorsal horn, somatostatin and spinal cord
17) Confidence 0.45 Published 1992 Journal Neuropeptides Section Title Doc Link 1361670 Disease Relevance 0.19 Pain Relevance 0.77
Effects of cysteamine on pain behaviour and on somatostatin- and substance P-like immunoreactivity in the substantia gelatinosa of the rat.
Regulation (Effects) of somatostatin in substantia gelatinosa associated with substantia gelatinosa, pain, qutenza, somatostatin and substance p
18) Confidence 0.45 Published 1984 Journal Eur. J. Pharmacol. Section Title Doc Link 6209149 Disease Relevance 0.36 Pain Relevance 1.35
Several reports have shown the analgesic effects of somatostatin and its analogues.
Regulation (effects) of somatostatin associated with analgesic and somatostatin
19) Confidence 0.45 Published 1998 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9565775 Disease Relevance 0.28 Pain Relevance 0.74
Effects of somatostatin (SST) on the synaptic transmission to substantia gelatinosa (SG) neurons of adult spinal cord slices were investigated using intracellular recording and blind whole-cell patch-clamp technique.
Spec (investigated) Regulation (Effects) of SST in spinal cord associated with substantia gelatinosa, somatostatin and spinal cord
20) Confidence 0.45 Published 2003 Journal Neurosci. Res. Section Abstract Doc Link 12941451 Disease Relevance 0 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox