INT100420

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.68
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
monocytes 1
epithelial cells 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 12 99.54 Very High Very High Very High
cva 21 97.96 Very High Very High Very High
Inflammation 35 88.48 High High
cINOD 4 85.84 High High
Analgesic 5 75.00 Quite High
addiction 3 49.48 Quite Low
opiate 2 49.08 Quite Low
ischemia 13 47.12 Quite Low
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 39 99.44 Very High Very High Very High
Cv General 3 Under Development 21 97.96 Very High Very High Very High
Congenital Anomalies 12 97.76 Very High Very High Very High
Apoptosis 11 96.96 Very High Very High Very High
Hyperlipidemia 18 96.24 Very High Very High Very High
Malaria 57 94.08 High High
Diabetes Mellitus 39 92.04 High High
Increased Venous Pressure Under Development 15 91.60 High High
Cerebral Malaria 33 91.52 High High
Coronary Artery Disease 34 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data on HO-1, TLR2, TLR4, and TNF-?
Regulation (data) of HO-1
1) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.15 Pain Relevance 0
In addition we observed no evidence of an up-regulation of HO-1 or GST in the bronchial tissues of subjects post wood smoke, which has previously been observed in cell models challenged with PM reflecting protective adaptation to the induction of oxidative stress [48].
Regulation (regulation) of HO-1 associated with stress
2) Confidence 0.28 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.25 Pain Relevance 0
Our results demonstrate that HO-1 is a novel target of AZD3582.
Regulation (target) of HO-1
3) Confidence 0.27 Published 2005 Journal Eur J Pharm Sci Section Abstract Doc Link 15911218 Disease Relevance 0.09 Pain Relevance 0.13
Our results suggest that the antioxidant defense protein HO-1 is a target of PPIs in both endothelial and gastric epithelial cells.
Regulation (target) of HO-1 in epithelial cells
4) Confidence 0.27 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.16 Pain Relevance 0.09
They also found that genotype L/L carriers are associated with higher extent of sever lipid peroxidation, supporting the genetic influence of HO-1 on oxidative stress.
Regulation (influence) of HO-1 associated with stress
5) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.26 Pain Relevance 0
No effect of HO-1 genotype could be observed in total population, they only have been observed in high risk group or low risk group.
Neg (No) Regulation (effect) of HO-1 genotype
6) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.56 Pain Relevance 0.07
It has been shown that the (GT)n repeat is highly polymorphic and modulates the transcriptional activity of HO-1 gene [23,24].
Regulation (modulates) of HO-1 gene
7) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.37 Pain Relevance 0.08
Morphine, de novo, had bimodal effects on HO activity: lower concentrations increased and higher concentrations decreased HO activity.
Regulation (effects) of HO associated with morphine
8) Confidence 0.21 Published 2003 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 12812915 Disease Relevance 0.74 Pain Relevance 0.92
Furthermore, the influence of the (GT)n repeat polymorphisms in the HO-1 gene promoter was investigated in different cell lines where constructs with lengths of less than 25 repeats (short repeat) showed an increasing HO-1 basal promoter activity [31] or transcriptional up-regulation in response to various stimuli as compared to that with greater than 25 repeats [15].
Spec (investigated) Regulation (influence) of HO-1 gene
9) Confidence 0.10 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 0.98 Pain Relevance 0
In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity.
Neg (without) Regulation (affecting) of cyclo-oxygenase-1 in monocytes
10) Confidence 0.07 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11779581 Disease Relevance 0.14 Pain Relevance 0.20

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