INT100422

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 46
Total Number 46
Disease Relevance 28.86
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
bladder 6
apoptotic cells 4
head 3
retinas 2
cartilage 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 6 100.00 Very High Very High Very High
fluoxetine 7 99.60 Very High Very High Very High
ischemia 426 99.46 Very High Very High Very High
tolerance 216 97.28 Very High Very High Very High
Central nervous system 6 93.72 High High
cINOD 18 93.16 High High
agonist 11 92.56 High High
Morphine 13 91.88 High High
nMDA receptor 4 88.92 High High
vanilloid receptor subtype 1 3 83.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 625 100.00 Very High Very High Very High
Lymphatic System Cancer 88 100.00 Very High Very High Very High
Dysmenorrhea 6 100.00 Very High Very High Very High
B-cell Acute Lymphoblastic Leukemia 1 100.00 Very High Very High Very High
Death 119 99.90 Very High Very High Very High
Diabetes Mellitus 82 99.84 Very High Very High Very High
Cancer 67 99.68 Very High Very High Very High
Necrosis 76 99.64 Very High Very High Very High
Cv Unclassified Under Development 347 99.46 Very High Very High Very High
Pressure And Volume Under Development 30 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin (1 mM) and ibuprofen (1 mM) significantly reduced Bcl-2 expression in the cancer cell lines tested and might be thought responsible for the observed increase in apoptosis.
Negative_regulation (reduced) of Gene_expression (expression) of Bcl-2 associated with cancer and apoptosis
1) Confidence 0.58 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 1.04 Pain Relevance 0.38
The expression of bcl-2 protein showed the same distribution as bcl-2mRNA, but gradually decreased in late hypertrophic zone, compared with strong expression of Bax throughout condylar cartilage.
Negative_regulation (decreased) of Gene_expression (expression) of bcl-2 protein in cartilage
2) Confidence 0.57 Published 2000 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 11780505 Disease Relevance 0.07 Pain Relevance 0
Moreover, Bcl2 expression was reduced in females exposed to A1254 at the neuroprotective dose of 0.1 mg/kg/day, suggesting that Bcl2 up-regulation is not required for PCB effects on infarct volume in these animals.
Negative_regulation (reduced) of Gene_expression (expression) of Bcl2
3) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.42 Pain Relevance 0.03
Ischemia for 1 h followed by 3 h reperfusion resulted in significant (P < 0.05) decreases in mRNA and protein expression of Bcl-2 when compared with L-arginine-treated rats [Figures 2 and 3].


Negative_regulation (decreases) of Gene_expression (expression) of Bcl-2 associated with ischemia
4) Confidence 0.56 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.65 Pain Relevance 0.08
The injury is mostly due to Bcl-xL downregulation rather than downregulation in Bcl-2 expression.
Negative_regulation (downregulation) of Gene_expression (expression) of Bcl-2 associated with injury
5) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.62 Pain Relevance 0.22
In vitro, a decrease in the expression of Bcl-2 has been reported in cultured retinal cells stimulated by various means, including simulated ischemia and excitotoxicity [19], whereas no obvious change in Bcl-2 gene expression was observed in vivo in retinas where ischemia was induced by increased IOP [1].
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-2 in retinas associated with ischemia and ocular hypertension
6) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.91 Pain Relevance 0.31
Compared with the untreated hearts, MS1 treatment significantly reduced myocardial infarct size (35.1% +/- 3% vs. 75.5% +/- 5%, p < 0.001), reduced prevalence of apoptotic cells (2.6% +/- 0.5% vs. 12.2% +/- 2.1%, p < 0.001), prevented mitochondrial swelling and cytochrome c release, inhibited downregulation of antiapoptotic protein Bcl-2 expression, and suppressed caspase-3 activation.
Negative_regulation (inhibited) of Gene_expression (expression) of Bcl-2 in apoptotic cells associated with pressure and volume under development, apoptosis and myocardial infarction
7) Confidence 0.47 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18066098 Disease Relevance 0.58 Pain Relevance 0.08
It also reversed the potassium cyanide-induced increased expression of Bax and decreased expression of Bcl-2 to control levels.
Negative_regulation (reversed) of Gene_expression (expression) of Bcl-2
8) Confidence 0.47 Published 2006 Journal Neuroscience Section Abstract Doc Link 16464535 Disease Relevance 0.82 Pain Relevance 0.05
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Negative_regulation (overall) of Gene_expression (expression) of bcl-2 associated with ischemia
9) Confidence 0.42 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.60 Pain Relevance 0.15
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Negative_regulation (lost) of Gene_expression (expression) of bcl-2 associated with ischemia
10) Confidence 0.42 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.56 Pain Relevance 0.15
Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3.
Negative_regulation (reveal) of Gene_expression (expression) of Bcl2
11) Confidence 0.42 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.67
Our results demonstrate a significant reduction in growth and an increase in apoptosis, possibly due to a reduction in Bcl-2 expression. after exposure to indomethacin and ibuprofen in the head and neck cancer cell lines tested.
Negative_regulation (reduction) of Gene_expression (expression.) of Bcl-2 in head associated with head & neck cancer and apoptosis
12) Confidence 0.42 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 1.02 Pain Relevance 0.33
These effects might exert through down-regulating Bcl-2 and BDNF mRNA expression in the hippocampus.


Negative_regulation (regulating) of Gene_expression (expression) of Bcl-2 in hippocampus
13) Confidence 0.42 Published 2005 Journal Zhonghua Er Ke Za Zhi Section Body Doc Link 16053732 Disease Relevance 0 Pain Relevance 0
Events like membrane depolarization of mitochondria, expression of Bax, Bcl2, externalization of phosphatidyl serine are substantially reversed by the pre-treatment of Fp extract.
Negative_regulation (reversed) of Gene_expression (expression) of Bcl2
14) Confidence 0.42 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19772912 Disease Relevance 0.68 Pain Relevance 0.06
In conclusion, the enhanced production of NO through the administration of L-arginine reduces necrosis and apoptosis by attenuated Bcl-2 expression in I/R-induced injury.
Negative_regulation (attenuated) of Gene_expression (expression) of Bcl-2 associated with necrosis, injury and apoptosis
15) Confidence 0.42 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.82 Pain Relevance 0
Apoptosis and necrosis associated marker gene Bcl-2 mRNA and protein expression were decreased in I/R group.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2 associated with necrosis and apoptosis
16) Confidence 0.42 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Abstract Doc Link PMC2841413 Disease Relevance 1.35 Pain Relevance 0.19
In the PND50 brain, A1254 at 0.1 mg/kg/day reduced Bcl2 expression in the female cortex (Figure 5B), whereas both A1254 doses increased Bcl2 in the male cortex (Figure 5D).
Negative_regulation (reduced) of Gene_expression (expression) of Bcl2 in cortex
17) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.18 Pain Relevance 0.03
Compared with the untreated hearts, MS1 treatment significantly reduced myocardial infarct size (35.1% +/- 3% vs. 75.5% +/- 5%, p < 0.001), reduced prevalence of apoptotic cells (2.6% +/- 0.5% vs. 12.2% +/- 2.1%, p < 0.001), prevented mitochondrial swelling and cytochrome c release, inhibited downregulation of antiapoptotic protein Bcl-2 expression, and suppressed caspase-3 activation.
Negative_regulation (downregulation) of Gene_expression (expression) of Bcl-2 in apoptotic cells associated with pressure and volume under development, apoptosis and myocardial infarction
18) Confidence 0.35 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18066098 Disease Relevance 0.58 Pain Relevance 0.08
It also reversed the potassium cyanide-induced increased expression of Bax and decreased expression of Bcl-2 to control levels.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2
19) Confidence 0.34 Published 2006 Journal Neuroscience Section Abstract Doc Link 16464535 Disease Relevance 0.79 Pain Relevance 0.05
In addition, western blot analysis also showed decreased Bcl-2 expression and increased Bax and caspase-3 expression.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2
20) Confidence 0.34 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 0.86 Pain Relevance 0

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