INT100423

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 141
Total Number 143
Disease Relevance 98.43
Pain Relevance 24.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
thymus 10
spleen 7
bladder 5
retinas 4
hippocampus 3
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 43 100.00 Very High Very High Very High
Hippocampus 60 99.98 Very High Very High Very High
Morphine 47 99.84 Very High Very High Very High
Ultiva 36 99.82 Very High Very High Very High
ischemia 886 99.76 Very High Very High Very High
Spinal cord 43 99.40 Very High Very High Very High
cerebral cortex 23 99.28 Very High Very High Very High
Sciatic nerve 22 99.20 Very High Very High Very High
Central nervous system 50 99.12 Very High Very High Very High
Clonidine 6 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 3322 100.00 Very High Very High Very High
Cancer 208 100.00 Very High Very High Very High
Colitis 181 99.86 Very High Very High Very High
Periodontitis 150 99.80 Very High Very High Very High
Neurodegenerative Disease 30 99.80 Very High Very High Very High
Cv Unclassified Under Development 529 99.76 Very High Very High Very High
Hypoxia 273 99.62 Very High Very High Very High
Acute Renal Failure 3 99.62 Very High Very High Very High
Injury 604 99.52 Very High Very High Very High
Myocardial Infarction 443 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mohd Yusof et al. determine the antiproliferative and apoptosis effects of hot water extract of Chlorella vulgaris on the hepatoma cell line, HepG2 and conclude that it may have anticancer effects possibly by inducing apoptosis signaling cascades via increased expression of P53, Bax and caspase?
Gene_expression (expression) of Bax associated with hepatocellular cancer and apoptosis
1) Confidence 0.75 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020329 Disease Relevance 0.82 Pain Relevance 0.07
Infarct size, bax expression, number of ventricular ectopic beats (VEB), duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) were significantly decreased in ischemic preconditioning and 3-NP pretreatment groups, whereas bcl-2 values were not markedly changed in these groups during occlusion period.
Gene_expression (expression) of bax associated with heart rate under development, arrhythmias 2 under development and arrhythmia under development
2) Confidence 0.75 Published 2008 Journal Life Sci. Section Abstract Doc Link 18387637 Disease Relevance 1.19 Pain Relevance 0.20
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Gene_expression (expression) of bax associated with cancer, apoptosis and death
3) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.61 Pain Relevance 0
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Gene_expression (expression) of bax associated with cancer, apoptosis and death
4) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.67 Pain Relevance 0
Hippocampus bcl-2 and bax expression and neuronal apoptosis after moderate hypothermic cardiopulmonary bypass in rats.
Gene_expression (expression) of bax in neuronal associated with hippocampus and neurodegenerative disease
5) Confidence 0.75 Published 2006 Journal Anesth. Analg. Section Title Doc Link 16551891 Disease Relevance 0.40 Pain Relevance 0.24
In rats, moderate hypothermic CPB with hemodilution is associated with CA1 hippocampus bax and bcl-2 gene expression and neuronal apoptosis during the early post-CPB recovery period.
Gene_expression (expression) of bax in hippocampus associated with hippocampus and neurodegenerative disease
6) Confidence 0.75 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.33 Pain Relevance 0.21
Like Fas-L, bax was also not detectable in controls (fig 3 A,B), but was increased in animals with colitis (fig. 3 C,D), especially in the crypt compartment.
Neg (not) Gene_expression (detectable) of bax associated with colitis
7) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.86 Pain Relevance 0.42
(fig. 3 I,J) prevented the expression of bax in the ileal enterocytes.
Gene_expression (expression) of bax in enterocytes
8) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.84 Pain Relevance 0.45
On Western-blot analysis (fig. 4) bax was expressed strongly in the ileal mucosa of animals with colitis at 3 and 6h.
Gene_expression (expressed) of bax associated with colitis
9) Confidence 0.75 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.75 Pain Relevance 0.45
Coronary reperfusion following ischemia: different expression of bcl-2 and bax proteins, and cardiomyocyte apoptosis.
Gene_expression (expression) of bax in cardiomyocyte associated with ischemia and apoptosis
10) Confidence 0.75 Published 2001 Journal Jpn Heart J Section Title Doc Link 11933925 Disease Relevance 0.60 Pain Relevance 0.13
To this end, we studied the expression of the pro- and anti-apoptotic factors, bax and bcl-2, respectively, in reperfused ischemic hearts and in hearts injected with bFGF or saline.
Gene_expression (expression) of bax in hearts associated with apoptosis
11) Confidence 0.75 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.50 Pain Relevance 0.12
High glucose also causes a 2 fold increase in Bax expression, which induced cytochrome C release which in turn stimulates apoptosis activating factor, caspase 9 and caspase 3 [41].
Gene_expression (expression) of Bax associated with apoptosis
12) Confidence 0.75 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 1.10 Pain Relevance 0.04
Furthermore, both PF and PN decreased the caspase-3 and Bax expressions but up-regulated Bcl-2 in the left ventricles.
Gene_expression (expressions) of Bax in ventricles
13) Confidence 0.73 Published 2008 Journal Planta Med. Section Abstract Doc Link 18203054 Disease Relevance 0.47 Pain Relevance 0.19
Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3.
Gene_expression (expression) of Bax
14) Confidence 0.73 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.67
METHODS: PCD, expression of both mRNA and protein of bcl-2 and expression of bax protein were observed by Tdt-mediated dUIP nick end labeling (TUNEL), mRNA in situ hybridization and immunohistochemical staining in TMJ of SD rats during series prenatal and postnatal developmental periods.
Gene_expression (expression) of bax
15) Confidence 0.72 Published 2000 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 11780505 Disease Relevance 0.10 Pain Relevance 0
The expression of bcl-2 protein showed the same distribution as bcl-2mRNA, but gradually decreased in late hypertrophic zone, compared with strong expression of Bax throughout condylar cartilage.
Gene_expression (expression) of Bax in cartilage
16) Confidence 0.72 Published 2000 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Body Doc Link 11780505 Disease Relevance 0.07 Pain Relevance 0
We hypothesized that HD affected the expression of Bcl-2, Bax and Caspase-3 in the central nervous system (CNS) and the peripheral nervous system (PNS).
Gene_expression (expression) of Bax in peripheral nervous system associated with peripheral nervous system and central nervous system
17) Confidence 0.72 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.31 Pain Relevance 0.29
Subchronic exposure to HD resulted in significantly increased expression of both anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax and Caspase-3 in cerebral cortex and cerebellum, which exhibited a dose-dependent pattern.
Gene_expression (expression) of Bax in cerebral cortex associated with apoptosis and cerebral cortex
18) Confidence 0.72 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.50 Pain Relevance 0.46
Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione.
Gene_expression (Expression) of Bax in nerve
19) Confidence 0.72 Published 2007 Journal Neurochem. Res. Section Title Doc Link 17492505 Disease Relevance 0.42 Pain Relevance 0.34
Though little change was detected in spinal cord, our results showed that the expression of Bcl-2, Bax and Caspase-3 was markedly enhanced in the sciatic nerves.
Gene_expression (expression) of Bax in sciatic nerves associated with sciatic nerve and spinal cord
20) Confidence 0.72 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.49 Pain Relevance 0.46

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