INT100427

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.63
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
enteroendocrine cells 1
liver 1
monocytes 1
smooth muscle cells 1
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 7 100.00 Very High Very High Very High
Inflammation 47 99.76 Very High Very High Very High
spinal inflammation 91 98.96 Very High Very High Very High
Serotonin 3 97.92 Very High Very High Very High
Pain 2 84.56 Quite High
Crohn's disease 1 67.68 Quite High
Bile 2 66.00 Quite High
rheumatoid arthritis 38 65.04 Quite High
Osteoarthritis 36 64.48 Quite High
corticosteroid 14 54.56 Quite High
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 34 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 100.00 Very High Very High Very High
Syndrome 7 99.92 Very High Very High Very High
Panniculitis 18 99.82 Very High Very High Very High
INFLAMMATION 57 99.76 Very High Very High Very High
Skin Diseases 6 99.56 Very High Very High Very High
Necrosis 6 99.24 Very High Very High Very High
Low Back Pain 90 98.96 Very High Very High Very High
Cirrhosis 36 98.90 Very High Very High Very High
Pulmonary Emphysema 9 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hereditary alpha-1-antitrypsin deficiency and its clinical consequences

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum.

AAT Binding (characterized) of in liver associated with cirrhosis, skin diseases, pulmonary emphysema and panniculitis
1) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Title Doc Link PMC2441617 Disease Relevance 1.10 Pain Relevance 0
It is less inconvenient for the children when first the other parent is investigated by isoelectric focusing or genotyping for alpha-1-antitrypsin.
alpha-1-antitrypsin Binding (genotyping) of
2) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.67 Pain Relevance 0
Likewise, Z-type alpha-1-antitrypsin from monocytes also polymerize within these cells and can only be secreted at very low levels.


Z-type alpha-1-antitrypsin Binding (polymerize) of in monocytes
3) Confidence 0.33 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.43 Pain Relevance 0
The MM2 phenotype, which is responsible for both normal A1AT concentration in serum and its function, is less frequent in these patients.
A1AT Binding (concentration) of associated with alpha-1-antitrypsin deficiency
4) Confidence 0.32 Published 2001 Journal Rocz. Akad. Med. Bialymst. Section Abstract Doc Link 11780580 Disease Relevance 0.97 Pain Relevance 0.44
PI-IBS is associated with modest increases in mucosal T lymphocytes and serotonin-containing enteroendocrine cells.
PI-IBS Binding (associated) of in enteroendocrine cells associated with spastic colon and serotonin
5) Confidence 0.31 Published 2003 Journal Gastroenterology Section Abstract Doc Link 12761724 Disease Relevance 1.20 Pain Relevance 0.86
The association of A1AT with inflammatory and coagulation pathways and the A1AT link to HDL and its functional properties are interesting considerations suggesting a pleiotropic beneficial effect of A1AT, which the deficient state exposes [8,9,28].
A1AT Binding (association) of associated with alpha-1-antitrypsin deficiency, inflammation and disorder of lipid metabolism
6) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC3004850 Disease Relevance 1.34 Pain Relevance 0.24
Increased levels of the complex of immunoglobulin with A-alpha 1 antitrypsin have been detected in the serum of AS patients and were associated with a clinical index of the disease [9,10].
antitrypsin Binding (complex) of associated with spinal inflammation and disease
7) Confidence 0.10 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.86 Pain Relevance 0.88
In addition to its presence in the lungs, circulating A1AT also binds to the endothelium [7], has a protective role in limiting vascular damage and is involved in the regulation of vascular smooth muscle cells and control of inflammatory pathways [8,9].
A1AT Binding (binds) of in smooth muscle cells associated with alpha-1-antitrypsin deficiency and inflammation
8) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC3004850 Disease Relevance 1.04 Pain Relevance 0.08
Both control and DLS-treated HepG2 cells showed hardly any evidence of necrosis.Fig. 2Effect of DLS on the Annexin V/PI binding of HepG2 and L-02 cells.
PI Binding (binding) of associated with necrosis
9) Confidence 0.02 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.57 Pain Relevance 0

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