INT100440

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.23

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mitochondrion (AGXT) small molecule metabolic process (AGXT) peroxisome (AGXT)
cellular nitrogen compound metabolic process (AGXT)
AGXT (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 4 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 4 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5'-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p.
Negative_regulation (inactivate) of Spec (like) Positive_regulation (inactivate) of SPT associated with hsan
1) Confidence 0.02 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11781309 Disease Relevance 0.23 Pain Relevance 0.23

General Comments

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