INT10045

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Context Info
Confidence 0.43
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.01
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1)
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 14 99.72 Very High Very High Very High
Deafferentation 4 99.32 Very High Very High Very High
Endep 1 98.50 Very High Very High Very High
Desipramine 7 98.20 Very High Very High Very High
fluoxetine 12 97.16 Very High Very High Very High
antidepressant 86 97.00 Very High Very High Very High
Inflammation 4 84.40 Quite High
Spinal cord 1 78.24 Quite High
induced neuropathy 1 67.84 Quite High
Hippocampus 4 62.52 Quite High
Disease Link Frequency Relevance Heat
Eczema 8 97.44 Very High Very High Very High
Neuropathic Pain 3 91.32 High High
INFLAMMATION 4 84.40 Quite High
Toxicity 1 79.88 Quite High
Injury 2 73.44 Quite High
Depression 19 50.00 Quite Low
Erythema 2 29.60 Quite Low
Pressure And Volume Under Development 2 28.80 Quite Low
Keloid Scars 2 25.00 Low Low
Pruritus 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of 1 mM of desipramine, amitriptyline, imipramine, iprindole, clomipramine and mianserin in vitro significantly inhibited (30-60%) PI synthetase activity, whereas the same concentration of zimelidine and fluoxetine had no effect.
Negative_regulation (inhibited) of PI associated with desipramine, endep and fluoxetine
1) Confidence 0.43 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2845289 Disease Relevance 0 Pain Relevance 0.27
Nitric oxide precursor L-arginine had a normalizing effect on reduced activity of alpha(1)-antitrypsin after capsaicin deafferentation.
Negative_regulation (reduced) of antitrypsin associated with qutenza and deafferentation
2) Confidence 0.39 Published 2008 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 19240864 Disease Relevance 0 Pain Relevance 0.62
Others were pretreated with 50 mg/kg of the mixed-function oxidase inhibitor, piperonyl butoxide (PiPB), 1 h before administering TOCP.
Negative_regulation (inhibitor) of PiPB
3) Confidence 0.36 Published 1984 Journal Exp. Neurol. Section Abstract Doc Link 6088273 Disease Relevance 0.09 Pain Relevance 0.11
Deafferentation with capsaicin was followed by a decrease in alpha(1)-antitrypsin activity.
Negative_regulation (decrease) of antitrypsin associated with qutenza and deafferentation
4) Confidence 0.33 Published 2008 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 19240864 Disease Relevance 0 Pain Relevance 0.59
First, we tested the effects of the general PI metabolism inhibitor, neomycin, against the maximally effective concentrations of the selected antidepressant agents.
Negative_regulation (inhibitor) of PI associated with antidepressant
5) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.39
Alpha 1-proteinase inhibitor (alpha 1-PI), a serine protease inhibitor, was tested for its efficacy for the treatment of recalcitrant atopic dermatitis.
Negative_regulation (inhibitor) of Alpha 1-proteinase associated with eczema
6) Confidence 0.02 Published 1992 Journal Ann Allergy Section Abstract Doc Link 1456482 Disease Relevance 0.41 Pain Relevance 0.04
Alpha 1-proteinase inhibitor (alpha 1-PI), a serine protease inhibitor, was tested for its efficacy for the treatment of recalcitrant atopic dermatitis.
Negative_regulation (inhibitor) of Alpha 1-proteinase associated with eczema
7) Confidence 0.02 Published 1992 Journal Ann Allergy Section Abstract Doc Link 1456482 Disease Relevance 0.42 Pain Relevance 0.04

General Comments

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