INT100458

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.55
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTA) extracellular space (LTA) extracellular region (LTA)
cell-cell signaling (LTA)
Anatomy Link Frequency
muscles 3
arm 1
LTA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 51 83.24 Quite High
corticosteroid 74 82.16 Quite High
peptic ulcer disease 2 81.72 Quite High
Inflammation 55 81.16 Quite High
Inflammatory marker 2 72.40 Quite High
cINOD 2 59.12 Quite High
depression 3 50.00 Quite Low
rheumatoid arthritis 8 47.36 Quite Low
Arthritis 1 14.36 Low Low
fibrosis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peptic Ulcer 4 98.80 Very High Very High Very High
Renal Disease 57 98.72 Very High Very High Very High
Duodenal Ulcer 6 98.52 Very High Very High Very High
Immunization 108 98.48 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 32 97.64 Very High Very High Very High
Recurrence 46 96.04 Very High Very High Very High
Hepatitis C Virus Infection 104 95.60 Very High Very High Very High
Cerebrovascular Disease 2 95.56 Very High Very High Very High
Ulcers 10 94.60 High High
Diabetes Mellitus 153 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variation in TNF and LTA genes has been associated with diabetic nephropathy [15], retinopathy [16] as well as with cardiovascular and cerebrovascular disease [17], [18].
Positive_regulation (Variation) of LTA associated with cerebrovascular disease, renal disease and ocular toxicity (including many sub-types)
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.13 Pain Relevance 0.07
Patients with gastric ulcer had a lower frequency of the TNF-308 allele 2 and a higher frequency of the LTANcoI 2.2 genotype when compared with duodenal ulcer patients (P < 0.01 and P = 0.03, respectively).
Positive_regulation (frequency) of LTA associated with duodenal ulcer and peptic ulcer
2) Confidence 0.49 Published 2001 Journal Genes Immun. Section Abstract Doc Link 11781708 Disease Relevance 1.62 Pain Relevance 0.29
LTA, TNF and the gene encoding for RAGE (AGER) are all located within the MHC complex on the short arm of chromosome 6.
Positive_regulation (located) of LTA in arm
3) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.28 Pain Relevance 0.20
Masseter (LMM, 17.05; RMM, 16.30), and the anterior temporalis muscles (LTA, 17.81; RTA, 17.69) were activated during swallowing, but had a lower SEMG value than the submental group.
Positive_regulation (activated) of LTA in muscles
4) Confidence 0.33 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
A highly significant difference (p = 0.0001) existed between the SOC and SNOC groups in all the SEMG activation of the stomatognatic muscles (LTA, RTA, LMM, RMM).
Positive_regulation (activation) of LTA in muscles
5) Confidence 0.33 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
After second immunization mean peak IgG titer to LT 4743 (peak fold increase 3.7), mean peak IgA ASC response to LT 0.9, mean peak IgG titer to LPS 3672 (16.5) mean peak IgA ASC response to LPS 15.7.
Positive_regulation (response) of LT associated with immunization
6) Confidence 0.31 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.35 Pain Relevance 0
The lack of appreciable side effects combined with the induction of anti-LT specific immune responses in the majority of vaccines support the further development of ETEC Vaccine 1 as an effective ETEC vaccine.
Positive_regulation (induction) of anti-LT
7) Confidence 0.31 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.14 Pain Relevance 0
For subjects receiving 109 CFU: After first immunization mean peak IgG titer to LT 4184 (peak fold increase 4.2), mean peak IgA ASC response to LT 8.29, mean peak IgG titer to LPS 3724 (13.1), mean peak IgA ASC response to LPS 158.
Positive_regulation (response) of LT associated with immunization
8) Confidence 0.27 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.36 Pain Relevance 0
A highly significant difference (p = 0.0001) existed between the SOC and SNOC groups in all the SEMG activation of the stomatognatic muscles (LTA; RTA, LMM, RMM).
Positive_regulation (activation) of LTA in muscles
9) Confidence 0.22 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0.14 Pain Relevance 0
This effect of PHA-induced proliferation was somewhat mirrored in the production of PHA-induced LT.
Positive_regulation (induced) of LT
10) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0.10
These studies continue to reinforce the importance of ATG as a steroid-sparing agent during the induction phase of LT and for the treatment of ACR.
Positive_regulation (induction) of LT
11) Confidence 0.08 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 1.29 Pain Relevance 0.10
This seminal work led to an important study by McAlister et al. who reported their experience with sirolimus in combination with tacrolimus in 32 solid organ recipients of whom 23 had undergone LT [55].
Positive_regulation (undergone) of LT
12) Confidence 0.07 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.23 Pain Relevance 0.04

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