INT100461

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) aging (Sod2)
mitochondrion organization (Sod2) DNA binding (Sod2) response to stress (Sod2)
Anatomy Link Frequency
spinal cord 2
Sod2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 99.20 Very High Very High Very High
Spinal cord 9 98.24 Very High Very High Very High
ischemia 9 96.80 Very High Very High Very High
tolerance 1 78.04 Quite High
Neurobehavioral 1 63.76 Quite High
orphanin 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 98.04 Very High Very High Very High
Spinal Cord Ischemia 6 96.80 Very High Very High Very High
Pressure Volume 2 Under Development 1 95.52 Very High Very High Very High
Hypoxia 3 87.00 High High
Intracranial Hypertension 1 86.64 High High
Apoptosis 3 82.00 Quite High
Neurodegenerative Disease 1 60.96 Quite High
Hypotension 4 50.00 Quite Low
Cv Unclassified Under Development 1 50.00 Quite Low
Reperfusion Injury 1 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HBO-PC enhanced activities of Mn-superoxide dismutase (Mn-SOD) and catalase, as well as the expression of Bcl-2 in the mitochondria in the normal spinal cord at 24 h after the last pretreatment (before spinal cord ischemia), and retained higher levels throughout the early reperfusion in the ischemic spinal cord.
Positive_regulation (enhanced) of Gene_expression (expression) of Mn-superoxide dismutase in spinal cord associated with ischemia and spinal cord
1) Confidence 0.28 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.82 Pain Relevance 0.71
Coadministration of the PKC inhibitor chelerythrine (10-7M) or the O-2 scavenger polyethylene glycol superoxide dismutase and catalase (SODCAT) with NOC/oFQ (10-10M) partially prevented hypotensive pial dilation impairment (34I2 vs 28I1% for SODCAT).
Positive_regulation (Coadministration) of Spec (partially) Gene_expression (Coadministration) of O-2 scavenger polyethylene glycol superoxide dismutase
2) Confidence 0.05 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11782666 Disease Relevance 0.17 Pain Relevance 0

General Comments

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