INT100462

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.41
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) aging (Sod2)
mitochondrion organization (Sod2) DNA binding (Sod2) response to stress (Sod2)
Anatomy Link Frequency
spinal cord 1
bladder 1
Sod2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.24 Very High Very High Very High
anesthesia 2 98.28 Very High Very High Very High
Spinal cord 9 98.24 Very High Very High Very High
ischemia 18 95.88 Very High Very High Very High
tolerance 1 77.12 Quite High
Neurobehavioral 1 63.76 Quite High
orphanin 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 39 99.96 Very High Very High Very High
Stress 13 99.88 Very High Very High Very High
Infection 6 98.52 Very High Very High Very High
Death 1 97.12 Very High Very High Very High
Spinal Cord Ischemia 6 96.00 Very High Very High Very High
Pressure Volume 2 Under Development 1 94.60 High High
Hypoxia 4 87.00 High High
Intracranial Hypertension 1 86.64 High High
Injury 11 78.00 Quite High
Cv Unclassified Under Development 11 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, infection of AdSOD2-shRNA to Fisher 344 rats resulted in a significant decrease of SOD2 mRNA, protein expression, and SOD2 enzyme activity to 28%, 35%, and 39%, respectively, 7 days after infection.
Gene_expression (expression) of SOD2 associated with infection
1) Confidence 0.68 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.55 Pain Relevance 0.23
In this study, infection of AdSOD2-shRNA to Fisher 344 rats resulted in a significant decrease of SOD2 mRNA, protein expression, and SOD2 enzyme activity to 28%, 35%, and 39%, respectively, 7 days after infection.
Gene_expression (expression) of SOD2 associated with infection
2) Confidence 0.68 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.55 Pain Relevance 0.23
Heme oxygenase-1 protein, known to be induced by oxidative stress, was detected in SOD2-knockdown rats administered acetaminophen.
Gene_expression (detected) of SOD2-knockdown associated with stress and paracetamol
3) Confidence 0.68 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.55 Pain Relevance 0.27
HBO-PC enhanced activities of Mn-superoxide dismutase (Mn-SOD) and catalase, as well as the expression of Bcl-2 in the mitochondria in the normal spinal cord at 24 h after the last pretreatment (before spinal cord ischemia), and retained higher levels throughout the early reperfusion in the ischemic spinal cord.
Gene_expression (expression) of Mn-superoxide dismutase in spinal cord associated with ischemia and spinal cord
4) Confidence 0.38 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.82 Pain Relevance 0.71
We examined the extent of bladder apoptosis, expression of Mn-superoxide dismutase (Mn-SOD), Bcl-2, Bax, caspase 3 and poly (ADP-ribose) (PAR) in the bladder.
Gene_expression (expression) of Mn-superoxide dismutase in bladder associated with apoptosis
5) Confidence 0.14 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2967004 Disease Relevance 0.76 Pain Relevance 0.04
Coadministration of the PKC inhibitor chelerythrine (10-7M) or the O-2 scavenger polyethylene glycol superoxide dismutase and catalase (SODCAT) with NOC/oFQ (10-10M) partially prevented hypotensive pial dilation impairment (34I2 vs 28I1% for SODCAT).
Spec (partially) Gene_expression (Coadministration) of O-2 scavenger polyethylene glycol superoxide dismutase
6) Confidence 0.06 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11782666 Disease Relevance 0.17 Pain Relevance 0

General Comments

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