INT10047

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.27
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
plasma 2
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 86 97.52 Very High Very High Very High
Inflammation 13 85.36 High High
rheumatoid arthritis 38 73.84 Quite High
Osteoarthritis 36 70.28 Quite High
Potency 1 40.40 Quite Low
cytokine 4 39.16 Quite Low
Pain 2 25.00 Low Low
pruritus 1 25.00 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
peptic ulcer disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 4 100.00 Very High Very High Very High
Disease 32 98.72 Very High Very High Very High
Eczema 4 97.92 Very High Very High Very High
Low Back Pain 85 97.52 Very High Very High Very High
Arthritis 2 95.96 Very High Very High Very High
INFLAMMATION 17 85.36 High High
Injury 2 74.40 Quite High
Rheumatoid Arthritis 38 73.84 Quite High
Frailty 38 70.28 Quite High
Ulcers 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most common and clinically most important alleles leading to alpha-1-antitrypsin deficiency are the Z and S allele [24,30].
Positive_regulation (leading) of Negative_regulation (deficiency) of alpha-1-antitrypsin
1) Confidence 0.47 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0 Pain Relevance 0
RESULTS: Among the 262 patients 17 (6.5%) were positive for the PiZ alpha1AT deficiency, a frequency of the same magnitude as in the Swedish general population (4.7%).
Positive_regulation (positive) of Negative_regulation (deficiency) of alpha1AT
2) Confidence 0.19 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 10672831 Disease Relevance 0.08 Pain Relevance 0
Additionally, a significantly increased expression level of the alpha-1-antitrypsin (A1AT) precursor, which is an important plasma inhibitor of serine proteases, was detected in the synovial tissues of AS patients using a proteomic approach.
Positive_regulation (increased) of Negative_regulation (inhibitor) of A1AT in plasma associated with spinal inflammation and alpha-1-antitrypsin deficiency
3) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.77 Pain Relevance 0.79
Alpha 1-proteinase inhibitor (alpha 1-PI), a serine protease inhibitor, was tested for its efficacy for the treatment of recalcitrant atopic dermatitis.
Positive_regulation (tested) of Negative_regulation (inhibitor) of 1-PI associated with eczema
4) Confidence 0.03 Published 1992 Journal Ann Allergy Section Abstract Doc Link 1456482 Disease Relevance 0.43 Pain Relevance 0.04

General Comments

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