INT100479

Context Info Confidence 0.44 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.12

transport (Abcb1b) mitochondrion (Abcb1b) nucleus (Camk1d) ATPase activity (Abcb1b) kinase activity (Camk1d) cytoplasm (Camk1d)

Anatomy Link Frequency internal 1 Abcb1b (Mus musculus) Camk1d (Mus musculus)

Pain Link Frequency Relevance Heat agonist 2 75.00 Opioid 1 53.48

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results demonstrate that LC-MS is an appropriate assay methodology for mouse brain perfusion samples, that AR-M delta compounds may interact with P-gp in the BBB, and that the internal strategy can provide useful information concerning P-gp modulation by compounds of interest.

P-gp Binding (interact) of AR-M delta in internal

1) Confidence 0.44 Published 2002 Journal J Pharm Sci Section Abstract Doc Link 11782913 Disease Relevance 0 Pain Relevance 0.12

General Comments

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