INT10048

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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 8.59
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
plasma 1
neuron 1
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 172 99.92 Very High Very High Very High
cINOD 11 95.84 Very High Very High Very High
Inflammation 23 85.36 High High
headache 4 83.92 Quite High
palliative 2 83.44 Quite High
Potency 47 77.88 Quite High
rheumatoid arthritis 76 73.84 Quite High
Dysuria 1 72.12 Quite High
Osteoarthritis 74 70.28 Quite High
Glutamate 1 58.80 Quite High
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 13 100.00 Very High Very High Very High
Low Back Pain 170 99.92 Very High Very High Very High
Disease 69 98.72 Very High Very High Very High
Eczema 4 97.92 Very High Very High Very High
Stomach Cancer 4 97.68 Very High Very High Very High
Emphysema 21 97.28 Very High Very High Very High
Disorder Of Lipid Metabolism 8 95.96 Very High Very High Very High
Arthritis 4 95.96 Very High Very High Very High
INFLAMMATION 31 95.44 Very High Very High Very High
Granular Cell Tumor 5 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that the increasing levels of A1AT and A1AChy during chemotherapy after radical surgery for gastric cancer may point to the progress of the disease.
Positive_regulation (increasing) of A1AT associated with alpha-1-antitrypsin deficiency, disease and stomach cancer
1) Confidence 0.68 Published 1993 Journal Neoplasma Section Abstract Doc Link 7688868 Disease Relevance 0.86 Pain Relevance 0.16
An issue further supported by the observation that individuals with SZ and SS genotype (although significantly less clinical information is available about SS type patients), who on average have higher levels of alpha-1-antitrypsin than the Null and Z genotype, are less prone to the development of emphysema [20].
Positive_regulation (levels) of alpha-1-antitrypsin associated with emphysema
2) Confidence 0.47 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.75 Pain Relevance 0.09
In addition, Prolastin-C has improved purity and a higher concentration of alpha1-PI.
Positive_regulation (concentration) of alpha1-PI
3) Confidence 0.45 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0.07 Pain Relevance 0.08
Augmentation therapy with Prolastin® (Alpha1-Proteinase Inhibitor [Human]) to increase the levels of alpha1-PI has been used to treat individuals with AAT deficiency for over 20 years.
Positive_regulation (increase) of alpha1-PI
4) Confidence 0.42 Published 2010 Journal BMC Clin Pharmacol Section Abstract Doc Link PMC2958874 Disease Relevance 0.09 Pain Relevance 0
The epithelial component showed immunoreactivity for cytokeratin and EMA, while the mesenchymal component was diffusely reactive for vimentin, alpha-1-antitrypsin and lysozime.
Positive_regulation (reactive) of alpha-1-antitrypsin
5) Confidence 0.25 Published 2001 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 11484992 Disease Relevance 0.73 Pain Relevance 0.07
Additionally, a significantly increased expression level of the alpha-1-antitrypsin (A1AT) precursor, which is an important plasma inhibitor of serine proteases, was detected in the synovial tissues of AS patients using a proteomic approach.
Positive_regulation (increased) of A1AT in plasma associated with spinal inflammation and alpha-1-antitrypsin deficiency
6) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.74 Pain Relevance 0.78
During 1972-74, 200000 Swedish neonates were screened for alpha1-antitrypsin deficiency (alpha1ATD).
Positive_regulation (screened) of alpha1-antitrypsin deficiency
7) Confidence 0.17 Published 1999 Journal Acta Paediatr. Section Abstract Doc Link 10229044 Disease Relevance 0 Pain Relevance 0
Increased levels of the complex of immunoglobulin with A-alpha 1 antitrypsin have been detected in the serum of AS patients and were associated with a clinical index of the disease [9,10].
Positive_regulation (Increased) of antitrypsin associated with spinal inflammation and disease
8) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.87 Pain Relevance 0.89
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Positive_regulation (positive) of alpha-1-antitrypsin in neuron
9) Confidence 0.09 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.90 Pain Relevance 0.08
Alpha 1-proteinase inhibitor (alpha 1-PI), a serine protease inhibitor, was tested for its efficacy for the treatment of recalcitrant atopic dermatitis.
Positive_regulation (tested) of 1-PI associated with eczema
10) Confidence 0.03 Published 1992 Journal Ann Allergy Section Abstract Doc Link 1456482 Disease Relevance 0.43 Pain Relevance 0.04
HOCl inactivates alpha 1-antiprotease, permitting uncontrolled protease activities.
Positive_regulation (inactivates) of alpha 1-antiprotease
11) Confidence 0.01 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2825705 Disease Relevance 0.17 Pain Relevance 0.21
Seven proteins were increased after treatment, including leucine-rich alpha2-glycoprotein and alpha1-antitrypsin.
Positive_regulation (increased) of alpha1-antitrypsin
12) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.97 Pain Relevance 0.03

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