INT100488

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.85
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
paw 2
CSF 2
microglia 2
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 78 100.00 Very High Very High Very High
Inflammation 37 100.00 Very High Very High Very High
Multiple sclerosis 6 99.42 Very High Very High Very High
cytokine 84 96.80 Very High Very High Very High
Paracetamol 1 95.20 Very High Very High Very High
chemokine 23 92.64 High High
Neuritis 1 90.16 High High
Neuropathic pain 2 89.84 High High
COX-2 inhibitor 4 85.96 High High
Inflammatory response 9 83.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 55 100.00 Very High Very High Very High
Recurrence 1 99.82 Very High Very High Very High
Demyelinating Disease 6 99.42 Very High Very High Very High
Targeted Disruption 2 97.08 Very High Very High Very High
Hepatotoxicity 1 96.12 Very High Very High Very High
Disease 5 94.08 High High
Ocular & Orbital Inflammation 1 93.20 High High
Optic Neuritis 1 90.64 High High
Neuropathic Pain 4 89.84 High High
Convulsion 1 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study reported, in support of our observations, that selective pharmacological inhibition of COX-2 with NS-398 increases the transcription of inflammatory genes (mPGES-1, TLR2, CD14, MCP-1) in vascular associated brain cells and parenchymal microglia after systemic injection of LPS [14].
Negative_regulation (inhibition) of Positive_regulation (increases) of MCP-1 in microglia associated with inflammation
1) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.92 Pain Relevance 0.37
The knockout animals were unimpaired in their ability to produce mRNA for pro-IL-1beta, and cytometric analysis of paw and systemic cytokines from knockout and wild-type animals following adjuvant insult suggests a selective effect of the gene deletion on release of IL-1beta and IL-10, with systemic reductions in adjuvant-induced increases in IL-6 and MCP-1.
Negative_regulation (reductions) of Positive_regulation (increases) of MCP-1 in paw associated with targeted disruption and cytokine
2) Confidence 0.10 Published 2005 Journal Pain Section Abstract Doc Link 15777864 Disease Relevance 1.06 Pain Relevance 0.54
Pretreatment with 1 or 5 µM BAPTA/AM partially inhibited MCP-1 and IL-6, while BAPTA/AM at 10 µM completely abolished production of morphine and Tat-induced increases in MCP-1, IL-6 and TNF-?.
Negative_regulation (abolished) of Positive_regulation (increases) of MCP-1 associated with morphine
3) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.80
We previously reported that CSF concentrations of CXCL10 (previously known as IP-10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP-1) were reduced.
Negative_regulation (reduced) of Positive_regulation (levels) of MCP-1 in CSF associated with multiple sclerosis and recurrence
4) Confidence 0.01 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784351 Disease Relevance 0.87 Pain Relevance 0.62

General Comments

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