INT10049

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 56
Total Number 56
Disease Relevance 44.52
Pain Relevance 9.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
liver 5
lung 5
plasma 4
epithelium 2
platelet 1
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thoracotomy 43 100.00 Very High Very High Very High
Fibrositis 18 99.82 Very High Very High Very High
Perioperative pain 2 99.64 Very High Very High Very High
peptic ulcer disease 15 99.56 Very High Very High Very High
alcohol 21 99.44 Very High Very High Very High
headache 12 98.88 Very High Very High Very High
cINOD 21 98.04 Very High Very High Very High
spinal inflammation 93 97.52 Very High Very High Very High
Inflammation 126 97.00 Very High Very High Very High
Paracetamol 15 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 30 100.00 Very High Very High Very High
Lung Cancer 19 100.00 Very High Very High Very High
Iron Overload 32 99.92 Very High Very High Very High
Pulmonary Disease 476 99.90 Very High Very High Very High
Disease 240 99.90 Very High Very High Very High
Liver Disease 81 99.90 Very High Very High Very High
Collagen Disease 1 99.88 Very High Very High Very High
Congenital Anomalies 32 99.82 Very High Very High Very High
Fibromyalgia 16 99.82 Very High Very High Very High
Emphysema 283 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha-1-antitrypsin deficiency
Negative_regulation (deficiency) of Alpha-1-antitrypsin
1) Confidence 0.59 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.76 Pain Relevance 0
A1AT and A1AChy levels in the remission group tended to decrease but the values did not normalize as compared to healthy subjects.
Negative_regulation (decrease) of A1AT associated with alpha-1-antitrypsin deficiency
2) Confidence 0.58 Published 1993 Journal Neoplasma Section Abstract Doc Link 7688868 Disease Relevance 0.61 Pain Relevance 0.18
Further testing by a pulmonary specialist confirmed diagnosis of emphysema secondary to a deficiency of Alpha-1 Antitrypsin (AAT).
Negative_regulation (deficiency) of AAT associated with emphysema
3) Confidence 0.57 Published 2001 Journal Clin Lab Sci Section Abstract Doc Link 11760819 Disease Relevance 0.80 Pain Relevance 0.23
There were no known risk factor for liver carcinoma (like cirrhosis, positive hepatitis B serology, alcohol abuse, haemochromatosis or alpha 1-antitrypsin deficiency).
Negative_regulation (deficiency) of alpha 1-antitrypsin in liver associated with liver cancer, cirrhosis, iron overload, hepatitis and alcohol
4) Confidence 0.43 Published 1994 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 8187611 Disease Relevance 1.08 Pain Relevance 0.20
Alpha-1-antitrypsin deficiency is a genetic disorder that manifests clinically as pulmonary emphysema, liver cirrhosis and much less frequently as the skin disease panniculitis.


Negative_regulation (deficiency) of Alpha-1-antitrypsin in liver associated with cirrhosis, skin diseases, pulmonary emphysema and panniculitis
5) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.80 Pain Relevance 0
Hereditary alpha-1-antitrypsin deficiency and its clinical consequences

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum.

Negative_regulation (deficiency) of alpha-1-antitrypsin in liver associated with cirrhosis, skin diseases, pulmonary emphysema and panniculitis
6) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Title Doc Link PMC2441617 Disease Relevance 0.80 Pain Relevance 0
The most common and clinically most important alleles leading to alpha-1-antitrypsin deficiency are the Z and S allele [24,30].
Negative_regulation (deficiency) of alpha-1-antitrypsin
7) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0 Pain Relevance 0
Who should be tested how for alpha-1-antitrypsin deficiency?
Negative_regulation (deficiency) of alpha-1-antitrypsin
8) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.61 Pain Relevance 0.03
Yet, the importance of registries with phenotypical information about individuals with alpha-1-antitrypsin deficiency was recently illustrated [22].
Negative_regulation (deficiency) of alpha-1-antitrypsin
9) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.73 Pain Relevance 0.08
Alpha-1-antitrypsin deficiency with its many genotypes and its manifestation in various organs is rarely observed in daily clinical practice and is frequently not diagnosed or misdiagnosed.
Negative_regulation (deficiency) of Alpha-1-antitrypsin
10) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.15 Pain Relevance 0.24
Liver disease and alpha-1-antitrypsin deficiency
Negative_regulation (deficiency) of alpha-1-antitrypsin in Liver associated with liver disease
11) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.98 Pain Relevance 0.03
Lung disease and alpha-1-antitrypsin deficiency
Negative_regulation (deficiency) of alpha-1-antitrypsin in Lung associated with pulmonary disease
12) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.86 Pain Relevance 0.04
Skin disorders and alpha-1-antitrypsin deficiency
Negative_regulation (deficiency) of alpha-1-antitrypsin in Skin
13) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.17 Pain Relevance 0.08
At present, treatment options for alpha-1-antitrypsin deficiency are very limited.
Negative_regulation (deficiency) of alpha-1-antitrypsin
14) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.73 Pain Relevance 0
Like in emphysema patients without alpha-1-antitrypsin deficiency, relief of breathlessness may be obtained with long-acting bronchodilators and inhaled corticosteroids [36].
Neg (without) Negative_regulation (deficiency) of alpha-1-antitrypsin associated with emphysema, corticosteroid and dyspnea
15) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.10 Pain Relevance 0.18
Alpha-1 anti-trypsin deficiency and Henoch-Schönlein purpura associated with anti-neutrophil cytoplasmic and anti-endothelial cell antibodies of immunoglobulin-A isotype.
Negative_regulation (deficiency) of Alpha-1 anti-trypsin in endothelial cell associated with purpura
16) Confidence 0.43 Published 2005 Journal J. Cutan. Pathol. Section Title Doc Link 15769280 Disease Relevance 1.36 Pain Relevance 0.07
The prevalence of AAT deficiency in newborns has been estimated from large population studies, with a screening of all newborns in Sweden in 1972 to 1974 being most comprehensive [7].
Negative_regulation (deficiency) of AAT
17) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.30 Pain Relevance 0
We have evaluated the allele frequency of this polymorphism in FMS.Alpha1-antitrypsin (AAT) deficiency is an autosomal recessive metabolic disease.
Negative_regulation (deficiency) of AAT associated with metabolic disorder and fibrositis
18) Confidence 0.42 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 20074437 Disease Relevance 1.13 Pain Relevance 0.71
The clinical manifestations of AAT deficiency are strongly associated with the ZZ type of deficiency, but vary widely between patients with ZZ type may, ranging from asymptomatic in some to fatal liver or lung disease in others [10].
Negative_regulation (deficiency) of AAT in lung associated with pulmonary disease
19) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.55 Pain Relevance 0
The lung manifestations of AAT deficiency include emphysema and chronic obstructive pulmonary disease (COPD) [10].
Negative_regulation (deficiency) of AAT in lung associated with emphysema and pulmonary disease
20) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.80 Pain Relevance 0.04

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