INT100490

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.48
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
CSF 2
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 24 99.84 Very High Very High Very High
Multiple sclerosis 5 99.42 Very High Very High Very High
cINOD 8 91.36 High High
Neuritis 1 90.16 High High
dexamethasone 16 89.44 High High
Inflammation 10 75.00 Quite High
intrathecal 4 75.00 Quite High
metalloproteinase 4 27.44 Quite Low
Osteoarthritis 17 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 1 99.82 Very High Very High Very High
Demyelinating Disease 5 99.42 Very High Very High Very High
Disease 2 94.08 High High
INFLAMMATION 15 90.96 High High
Optic Neuritis 1 90.64 High High
Retinal Diseases 4 75.56 Quite High
Osteoarthritis 17 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Chondrosarcoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (induced) of MCP-1
1) Confidence 0.23 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.33
Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK.
Negative_regulation (abrogated) of Positive_regulation (Induction) of MCP-1
2) Confidence 0.23 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.16 Pain Relevance 0.37
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (induced) of MCP-1
3) Confidence 0.23 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.16 Pain Relevance 0.34
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (supporessed) of Positive_regulation (induced) of MCP-1
4) Confidence 0.23 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.29
Two-hour pre-treatment with 10 mM of both molecules significantly reverted the stimulation of IL-6, IL-8, ICAM-1 and Mcp-1, whereas the effect on I?
Negative_regulation (reverted) of Positive_regulation (stimulation) of Mcp-1
5) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
We previously reported that CSF concentrations of CXCL10 (previously known as IP-10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP-1) were reduced.
Negative_regulation (reduced) of Positive_regulation (levels) of CCL2 in CSF associated with multiple sclerosis and recurrence
6) Confidence 0.22 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784351 Disease Relevance 0.87 Pain Relevance 0.62

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox