INT100491

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.97
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
CSF 2
peripheral nerves 1
vesicles 1
Kupffer cells 1
Cxcl10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 265 100.00 Very High Very High Very High
Inflammation 128 100.00 Very High Very High Very High
cytokine 26 100.00 Very High Very High Very High
Multiple sclerosis 10 99.84 Very High Very High Very High
Inflammatory response 34 97.22 Very High Very High Very High
imagery 16 95.44 Very High Very High Very High
Calcitonin gene-related peptide 8 94.80 High High
Pain 36 94.36 High High
hyperexcitability 11 94.00 High High
Demyelination 96 91.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 165 100.00 Very High Very High Very High
Demyelinating Disease 109 99.84 Very High Very High Very High
Recurrence 2 99.24 Very High Very High Very High
Disease 8 97.40 Very High Very High Very High
Pain 57 94.36 High High
Experimental Arthritis 2 88.92 High High
Optic Neuritis 2 85.04 High High
Ganglion Cysts 44 84.40 Quite High
Nervous System Injury 64 83.24 Quite High
Injury 71 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Positive_regulation (packaged) of IP10 in vesicles associated with chemokine
1) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.55
We previously reported that CSF concentrations of CXCL10 (previously known as IP-10) were elevated in MS patients in relapse, whilst levels of CCL2 (MCP-1) were reduced.
Positive_regulation (elevated) of CXCL10 in CSF associated with multiple sclerosis and recurrence
2) Confidence 0.39 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784351 Disease Relevance 0.87 Pain Relevance 0.61
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Positive_regulation (activate) of IP-10 in peripheral nerves associated with chemokine
3) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.38 Pain Relevance 0.58
The levels of CXCL10 were higher in the patient group than in controls but two outliers in the control group also had high CSF concentrations of CXCL10.
Positive_regulation (concentrations) of CXCL10 in CSF
4) Confidence 0.28 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784351 Disease Relevance 0.79 Pain Relevance 0.80
IP-10, the ligand for the CXCR3 chemokine receptor, was not upregulated in this animal model (data not shown).
Neg (not) Positive_regulation (upregulated) of IP-10 associated with chemokine
5) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.25 Pain Relevance 0.60
IP-10 – Interferon inducible protein 10
Positive_regulation (inducible) of IP-10
6) Confidence 0.07 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.30 Pain Relevance 0.38
activated protein (IP-10) as well as their respective mRNA [33].
Positive_regulation (activated) of IP-10
7) Confidence 0.07 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.49 Pain Relevance 0.10
Moreover, CO has anti-inflammatory activity e.g. by inhibiting the inflammatory response of donor Kupffer cells upon transplantation [17], activation of anti-inflammatory mitogen-activated protein kinase signaling [18], and up-regulation of the anti-inflammatory cytokine IL-10 [19].
Positive_regulation (regulation) of cytokine IL-10 in Kupffer cells associated with inflammatory response, inflammation and cytokine
8) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.61 Pain Relevance 0.32

General Comments

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