INT100492

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.71
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
CSF 2
dermis 2
vesicles 2
Cxcl10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 334 99.98 Very High Very High Very High
qutenza 24 98.28 Very High Very High Very High
Inflammation 54 95.64 Very High Very High Very High
intrathecal 4 95.12 Very High Very High Very High
Demyelination 98 93.52 High High
cytokine 19 90.92 High High
Neuritis 1 83.28 Quite High
Multiple sclerosis 5 82.32 Quite High
Neuropathic pain 56 78.76 Quite High
metalloproteinase 3 73.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 71 95.64 Very High Very High Very High
Demyelinating Disease 107 93.52 High High
Aids-related Complex 4 88.76 High High
Optic Neuritis 1 83.28 Quite High
Neuropathic Pain 67 78.76 Quite High
Recurrence 1 76.28 Quite High
Disease 7 70.72 Quite High
Neuropathy 30 62.40 Quite High
Ganglion Cysts 86 61.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 44 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced protein 10 (IP-10/CXCL10), MCP1 and SDF1 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (induced) of Gene_expression (added) of CXCL10 associated with qutenza
1) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.15 Pain Relevance 0.34
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Positive_regulation (packaged) of Gene_expression (expressed) of IP10 in vesicles associated with chemokine
2) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.58
For all experiments, MCP-1, SDF1, RANTES and IP10 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (experiments) of Gene_expression (added) of IP10 associated with qutenza
3) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.09 Pain Relevance 0.27
The levels of CXCL10 were higher in the patient group than in controls but two outliers in the control group also had high CSF concentrations of CXCL10.
Positive_regulation (higher) of Gene_expression (levels) of CXCL10 in CSF
4) Confidence 0.26 Published 2001 Journal Eur. J. Neurol. Section Abstract Doc Link 11784351 Disease Relevance 0.77 Pain Relevance 0.72
A low expression of IP-10 on papillary dermis cells was observed on hind paws from rats treated with oATP alone, following either local (Fig. 6e) or intravenous injection (Fig. 6f).
Positive_regulation (following) of Gene_expression (expression) of IP-10 in dermis
5) Confidence 0.23 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.26 Pain Relevance 0.31
-induced protein 10 (IP-10/CXCL10), MCP1 and SDF1 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (induced) of Gene_expression (added) of IP-10 associated with qutenza
6) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.15 Pain Relevance 0.34

General Comments

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