INT100498

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.81
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
lung 2
nociceptor 2
dorsal horn 2
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 3 100.00 Very High Very High Very High
intrathecal 2 99.84 Very High Very High Very High
antagonist 18 99.60 Very High Very High Very High
Dorsal horn 1 99.12 Very High Very High Very High
Inflammation 35 97.46 Very High Very High Very High
substance P 12 96.72 Very High Very High Very High
nociceptor 3 95.72 Very High Very High Very High
Stimulus evoked pain 4 91.12 High High
Spinal cord 3 88.80 High High
qutenza 5 81.04 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 100.00 Very High Very High Very High
Nociception 10 99.90 Very High Very High Very High
Pulmonary Disease 26 99.88 Very High Very High Very High
INFLAMMATION 30 97.46 Very High Very High Very High
Hypersensitivity 5 91.12 High High
Inflammatory Pain 2 90.44 High High
Pneumonia 7 86.72 High High
Pain 3 83.00 Quite High
Emphysema 10 82.24 Quite High
Targeted Disruption 2 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like N/OFQ, nocistatin-induced nociception was abolished by i.pl. injection of pertussis toxin, phospholipase C inhibitor, or CP-99994, a neurokinin 1 receptor antagonist, indicating that nocistatin may elicit nociception through a substance P release from nociceptor endings via activation of Gi/o and phospholipase C.
Negative_regulation (abolished) of Positive_regulation (injection) of neurokinin 1 in nociceptor associated with nociception, bordatella infection, nociceptor, antagonist and substance p
1) Confidence 0.41 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.80 Pain Relevance 0.80
Inflammation of the airways and lung parenchyma plays a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and increased tachykinin levels are recovered from the airways of COPD patients.
Negative_regulation (recovered) of Positive_regulation (increased) of tachykinin in lung associated with pulmonary disease and inflammation
2) Confidence 0.24 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2689186 Disease Relevance 1.11 Pain Relevance 0.34
CFA also induced an upregulation of prodynorphin and neurokinin-1 (NK-1) in dorsal horn neurons, which was suppressed by intrathecal delivery of the MEK (MAP kinase kinase) inhibitor U0126.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of NK-1 in dorsal horn associated with dorsal horn neuron and intrathecal
3) Confidence 0.12 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11784793 Disease Relevance 0.90 Pain Relevance 0.92

General Comments

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