INT1005

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 1
Speculated 13
Reported most in Abstract
Documents 385
Total Number 406
Disease Relevance 26.31
Pain Relevance 244.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
stomach 26
neurons 19
spinal cord 10
brain 8
neural 7
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 2775 100.00 Very High Very High Very High
Calcitonin gene-related peptide 361 100.00 Very High Very High Very High
Enkephalin 329 100.00 Very High Very High Very High
antagonist 283 100.00 Very High Very High Very High
substance P 255 100.00 Very High Very High Very High
qutenza 254 100.00 Very High Very High Very High
gABA 245 100.00 Very High Very High Very High
Glutamate 172 100.00 Very High Very High Very High
Neuropeptide 136 100.00 Very High Very High Very High
Cholecystokinin 126 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vibrio Infection 14 100.00 Very High Very High Very High
Depression 27 99.92 Very High Very High Very High
Hyperinsulinism 8 99.90 Very High Very High Very High
Stress 86 99.84 Very High Very High Very High
Aging 3 99.80 Very High Very High Very High
INFLAMMATION 68 99.78 Very High Very High Very High
Natriuresis 27 99.74 Very High Very High Very High
Nociception 88 99.70 Very High Very High Very High
Diabetic Nephropathy 3 99.68 Very High Very High Very High
Urological Neuroanatomy 23 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of somatostatin (somatostatin-like immunoreactivity) from hippocampal slices during the development of hippocampal kindling in rats was measured under resting and depolarizing conditions.
Localization (release) of somatostatin associated with somatostatin
1) Confidence 0.81 Published 1992 Journal Neuroscience Section Abstract Doc Link 1361218 Disease Relevance 0 Pain Relevance 0.31
Somatostatin release is enhanced in the hippocampus of partially and fully kindled rats.
Localization (release) of Somatostatin in hippocampus associated with somatostatin and hippocampus
2) Confidence 0.81 Published 1992 Journal Neuroscience Section Title Doc Link 1361218 Disease Relevance 0.12 Pain Relevance 0.45
Somatostatin release measured under resting conditions was increased by 1.5 times in the stimulated hippocampus at stage 2 (P < 0.05) and by 2.2 and 1.7 times in both hippocampi at stage 5 (P < 0.01).
Localization (release) of Somatostatin in stage 5 associated with somatostatin and hippocampus
3) Confidence 0.81 Published 1992 Journal Neuroscience Section Abstract Doc Link 1361218 Disease Relevance 0.18 Pain Relevance 0.58
One week after the last of three consecutive stage 5 seizures (full seizure expression) or 48 h after the last stage 2 stimulation (preconvulsive stage), 50 mM KCl-induced somatostatin release was significantly higher (1.8 +/- 0.1, P < 0.01) than in shams (animals implanted with electrodes but not stimulated) in the stimulated and contralateral hippocampus.
Localization (release) of somatostatin in stage 5 associated with convulsion, somatostatin and hippocampus
4) Confidence 0.81 Published 1992 Journal Neuroscience Section Abstract Doc Link 1361218 Disease Relevance 0.20 Pain Relevance 0.59
In vivo release of somatostatin from rat hippocampus and striatum.
Localization (release) of somatostatin in striatum associated with somatostatin and hippocampus
5) Confidence 0.81 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8097306 Disease Relevance 0 Pain Relevance 0.35
Neuronal release of somatostatin in the rat striatum: an in vivo microdialysis study.
Localization (release) of somatostatin in striatum associated with somatostatin
6) Confidence 0.81 Published 1993 Journal Neuroscience Section Title Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.31
In the present experiments, to elucidate neural systems inhibiting the release of somatostatin from the primary afferent terminals, we examined the effects of serotonin, noradrenaline and gamma-aminobutyric acid on the capsaicin-evoked, dorsal-rhizotomy-sensitive and tetrodotoxin-insensitive release of immunoreactive somatostatin, 98.7% of which was somatostatin itself, from the dorsal-half slices of lumbar and cervical enlargements of rat spinal cord.
Localization (release) of somatostatin in spinal cord associated with tetrodotoxin, qutenza, noradrenaline, somatostatin, serotonin and spinal cord
7) Confidence 0.81 Published 1991 Journal Neurosci. Res. Section Abstract Doc Link 1674126 Disease Relevance 0.09 Pain Relevance 0.91
The present results suggest that the serotonergic systems exert an inhibitory effect on the release of somatostatin from the central terminals of primary sensory neurons.
Localization (release) of somatostatin in primary sensory neurons associated with somatostatin
8) Confidence 0.81 Published 1991 Journal Neurosci. Res. Section Abstract Doc Link 1674126 Disease Relevance 0.06 Pain Relevance 0.89
These results indicate that (i) the somatostatin measured is neuronally released in the striatum and (ii) microdialysis is a useful tool for examining the regulation of somatostatin release in the brain.
Localization (released) of somatostatin in brain associated with somatostatin
9) Confidence 0.81 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.63
These results indicate that (i) the somatostatin measured is neuronally released in the striatum and (ii) microdialysis is a useful tool for examining the regulation of somatostatin release in the brain.
Localization (release) of somatostatin in brain associated with somatostatin
10) Confidence 0.81 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.57
The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats.
Localization (secretion) of somatostatin associated with somatostatin
11) Confidence 0.81 Published 1985 Journal Regul. Pept. Section Abstract Doc Link 2859639 Disease Relevance 0 Pain Relevance 0.20
In separate studies, we demonstrated that perivagal treatment with the sensory neurotoxin capsaicin impaired pancreatic responses to CCK-8 but had no effect on the inhibitory action of somatostatin-14 on pancreatic secretion evoked by 2-deoxy-D-glucose, ruling out an effect of somatostatin on the vagal afferent pathway.
Localization (secretion) of somatostatin associated with qutenza and somatostatin
12) Confidence 0.81 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8103634 Disease Relevance 0 Pain Relevance 0.59
These findings provide further examples of coexistence of two peptides and indicate the possibility that somatostatin- and enkephalin-like peptides are co-released.
Localization (released) of somatostatin associated with somatostatin and enkephalin
13) Confidence 0.80 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 2887451 Disease Relevance 0 Pain Relevance 0.51
Application of c-SOM alone followed by ADES of DRASS significantly decreased the mechanical thresholds and increased the discharge rates of C and Adelta fibers, indicating that endogenous release of somatostatin plays a tonic inhibitory role on the cross-excitation between peripheral nerves.
Localization (release) of somatostatin in peripheral nerves associated with adelta and somatostatin
14) Confidence 0.80 Published 2008 Journal Brain Res. Section Abstract Doc Link 18640104 Disease Relevance 0 Pain Relevance 0.62
Increasing concentrations of glutamate stimulated somatostatin release in a dose-dependent manner.
Localization (release) of somatostatin associated with glutamate and somatostatin
15) Confidence 0.80 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 0.65
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Localization (release) of somatostatin in neurons associated with glutamate and somatostatin
16) Confidence 0.80 Published 1988 Journal Endocrinology Section Title Doc Link 2901950 Disease Relevance 0 Pain Relevance 0.91
The increase in somatostatin release elicited by glutamate or NMDA was selectively antagonized by DL-2-amino-5-phosphonovaleric acid and by thyenyl-phencyclidine, two specific antagonists of NMDA receptors.
Localization (release) of somatostatin associated with glutamate, nmda receptor, antagonist and somatostatin
17) Confidence 0.80 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 0.97
Glutamate-induced somatostatin release was not blocked by tetrodotoxin (1 microM) suggesting that tetrodotoxin-sensitive sodium-dependent action potentials are not involved in this effect.
Localization (release) of somatostatin associated with action potential, tetrodotoxin, glutamate and somatostatin
18) Confidence 0.80 Published 1988 Journal Endocrinology Section Abstract Doc Link 2901950 Disease Relevance 0 Pain Relevance 1.08
Kassinin and substance P stimulate somatostatin release in the rat.
Localization (release) of somatostatin associated with somatostatin and substance p
19) Confidence 0.79 Published 1981 Journal Clin. Sci. Section Title Doc Link 6170487 Disease Relevance 0 Pain Relevance 0.53
Somatostatin-stimulated 5-HT release was markedly inhibited by gamma-aminobutyric acid (GABA) (30 microM), but not by baclofen (30 microM) and met-enk (100 microM).
Localization (release) of Somatostatin associated with gaba and somatostatin
20) Confidence 0.79 Published 1984 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6209442 Disease Relevance 0 Pain Relevance 0.52

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