INT10051

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Context Info
Confidence 0.11
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.53
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 2
neutrophil 2
Paf (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 18 99.38 Very High Very High Very High
Brush evoked pain 96 98.22 Very High Very High Very High
cINOD 4 98.08 Very High Very High Very High
withdrawal 30 96.08 Very High Very High Very High
dorsal root ganglion 188 93.92 High High
cytokine 34 91.44 High High
allodynia 10 70.32 Quite High
Spinal cord 14 62.16 Quite High
Peripheral nerve injury 26 46.40 Quite Low
Thermal hyperalgesia 4 41.60 Quite Low
Disease Link Frequency Relevance Heat
Injury 10 99.32 Very High Very High Very High
Neuropathic Pain 132 98.22 Very High Very High Very High
Nervous System Injury 116 97.70 Very High Very High Very High
Neutropenia 1 94.20 High High
Ganglion Cysts 190 93.92 High High
INFLAMMATION 5 83.72 Quite High
Hyperalgesia 6 41.60 Quite Low
Pain 16 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the role of lysophospholipid-derived lipid mediators such as PAF and LPA in nerve injury-induced tactile allodynia, we administered PAFR and LPA receptor (LPAR) antagonists to nerve-injured rats because inhibitors of PAF and LPA biosynthetic enzymes are not available.
Negative_regulation (inhibitors) of Gene_expression (biosynthetic) of PAF in nerve associated with brush evoked pain, nervous system injury and antagonist
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.06 Pain Relevance 0.89
The threshold began to decrease 15 min after PAF injection and peaked at 45–60 min, then gradually recovered over 4 h (Fig. 9A).
Negative_regulation (decrease) of Gene_expression (injection) of PAF
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.13 Pain Relevance 0.89
Whether or not effects of IL-1 on the production of mediators such as nitric oxide and PAF is an underlying mechanism for the inhibitory effects on neutrophil function remains to be determined.
Neg (not) Spec (Whether) Negative_regulation (effects) of Gene_expression (production) of PAF in neutrophil
3) Confidence 0.07 Published 1992 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 1456666 Disease Relevance 0.34 Pain Relevance 0.31

General Comments

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