INT100520

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.30
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1)
signal transducer activity (Grm1)
Anatomy Link Frequency
nervous system 1
Grm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 100.00 Very High Very High Very High
antagonist 25 99.92 Very High Very High Very High
drug abuse 1 99.88 Very High Very High Very High
anticonvulsant 1 99.80 Very High Very High Very High
Glutamate 3 99.04 Very High Very High Very High
IPN 1 98.98 Very High Very High Very High
depression 9 98.72 Very High Very High Very High
Morphine 42 97.72 Very High Very High Very High
tolerance 8 97.36 Very High Very High Very High
Intracerebroventricular 1 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 1 99.88 Very High Very High Very High
Disease 1 99.58 Very High Very High Very High
Anxiety Disorder 3 99.16 Very High Very High Very High
Inflammatory Pain 1 98.98 Very High Very High Very High
Depression 9 98.72 Very High Very High Very High
Neurological Disease 1 96.76 Very High Very High Very High
Morphine Dependence 3 68.76 Quite High
Adhesions 2 61.88 Quite High
Opiate Addiction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice.
Regulation (effects) of mGluR1 associated with antagonist, withdrawal and morphine
1) Confidence 0.44 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17222405 Disease Relevance 0.07 Pain Relevance 1.04
The aim of the present study was to compare the influence of group I metabotropic glutamate receptor (mGluR) antagonists (mGluR1 and mGluR5) on the expression of sensitization to the locomotor effect of morphine.
Regulation (influence) of I metabotropic glutamate receptor associated with antagonist, glutamate receptor and morphine
2) Confidence 0.23 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17222405 Disease Relevance 0.06 Pain Relevance 0.78
The aim of the present study was to compare the influence of group I metabotropic glutamate receptor (mGluR) antagonists (mGluR1 and mGluR5) on the expression of sensitization to the locomotor effect of morphine.
Regulation (influence) of mGluR associated with antagonist, glutamate receptor and morphine
3) Confidence 0.23 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17222405 Disease Relevance 0.06 Pain Relevance 0.83
CONCLUSION: Both mGluR5 and mGluR1 antagonists are effective in models of pain and anxiety.
Regulation (effective) of mGluR1
4) Confidence 0.10 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15682298 Disease Relevance 0 Pain Relevance 0
OBJECTIVES: This study was conducted to investigate the role of the mGluR5 and mGluR1 subtypes in the modulation of pain and anxiety.
Regulation (role) of mGluR1
5) Confidence 0.10 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15682298 Disease Relevance 0 Pain Relevance 0
Several molecules involved in RP, such as CaMKII, mGluR1, and Src, are also involved in LTD (Ito, 2001; Hansel et al, 2001, 2006; Tsuruno et al, 2008).
Regulation (involved) of mGluR1 associated with depression
6) Confidence 0.01 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.62 Pain Relevance 0.28
Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice.
Regulation (Effects) of mGlu1 associated with glutamate, antagonist, tolerance and morphine
7) Confidence 0.00 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15178357 Disease Relevance 0 Pain Relevance 1.06
More recent studies to assess the potential of these compounds in in vivo models of nervous system disorders have implicated the mGlu5 receptor subtype as a potentially important therapeutic target for inflammatory pain, anxiety, Parkinson's disease and drug abuse, and mGlu1 and mGlu5 receptors as potential targets for anticonvulsant and neuroprotective therapies.
Regulation (targets) of mGlu1 in nervous system associated with neurological disease, drug abuse, ipn, anxiety disorder, anticonvulsant and disease
8) Confidence 0.00 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 11786307 Disease Relevance 0.49 Pain Relevance 0.48

General Comments

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