INT100523

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM5) cytoplasm (GRM5) signal transducer activity (GRM5)
Anatomy Link Frequency
nervous system 1
GRM5 (Homo sapiens)
Pain Link Frequency Relevance Heat
anticonvulsant 1 99.80 Very High Very High Very High
drug abuse 1 99.68 Very High Very High Very High
agonist 4 99.36 Very High Very High Very High
IPN 1 98.78 Very High Very High Very High
opioid receptor 11 98.72 Very High Very High Very High
antagonist 3 97.12 Very High Very High Very High
Glutamate receptor 6 86.64 High High
Glutamate 2 79.68 Quite High
Enkephalin 1 78.56 Quite High
tolerance 1 65.96 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 99.68 Very High Very High Very High
Disease 1 99.38 Very High Very High Very High
Anxiety Disorder 1 98.96 Very High Very High Very High
Inflammatory Pain 1 98.78 Very High Very High Very High
Neurological Disease 1 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that an allosteric modulation of mGluR5 can affect the agonist-induced MOR signalling and regulation.
Regulation (modulation) of mGluR5 associated with agonist and opioid receptor
1) Confidence 0.26 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.03
More recent studies to assess the potential of these compounds in in vivo models of nervous system disorders have implicated the mGlu5 receptor subtype as a potentially important therapeutic target for inflammatory pain, anxiety, Parkinson's disease and drug abuse, and mGlu1 and mGlu5 receptors as potential targets for anticonvulsant and neuroprotective therapies.
Regulation (targets) of mGlu5 in nervous system associated with neurological disease, drug abuse, ipn, anxiety disorder, anticonvulsant and disease
2) Confidence 0.12 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 11786307 Disease Relevance 0.49 Pain Relevance 0.48

General Comments

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