INT100540

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.67
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
nucleus 4
nerve 1
proximal 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 2 98.96 Very High Very High Very High
cytokine 74 98.56 Very High Very High Very High
Potency 28 98.12 Very High Very High Very High
agonist 4 94.72 High High
fibrosis 101 87.04 High High
antagonist 9 82.00 Quite High
Pain 2 81.88 Quite High
psoriasis 98 81.60 Quite High
spastic colon 1 80.60 Quite High
Inflammation 102 79.12 Quite High
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 4 99.80 Very High Very High Very High
Apoptosis 55 96.60 Very High Very High Very High
Pulmonary Fibrosis 68 87.04 High High
Autoimmune Disease 16 86.80 High High
Pain 1 81.88 Quite High
Psoriasis 109 81.60 Quite High
Functional Bowel Disorder 1 80.60 Quite High
Peptic Ulcer 1 79.44 Quite High
INFLAMMATION 115 79.12 Quite High
Disease 78 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STATISTICA, release 7 (Stat Soft Scandinavia AB, Tulsa, OK, USA) was used for statistical analysis.
Localization (release) of Stat
1) Confidence 0.78 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.07 Pain Relevance 0.03
PURPOSE: To identify predictors of outcome and of electrophysiologic recovery in patients with carpal tunnel syndrome (CTS) treated by endoscopic carpal tunnel release using a nerve conduction testing system (NC-Stat; NEUROMetrix, Inc, Waltham, MA).
Localization (release) of Stat in nerve associated with carpal tunnel syndrome
2) Confidence 0.68 Published 2004 Journal J Hand Surg Am Section Abstract Doc Link 15140473 Disease Relevance 0.27 Pain Relevance 0.10
A 12-mm segment of proximal duodenum with an intact blood supply was cannulated in situ in anesthetized rats and duodenal HCO3- secretion titrated by pH-stat.
Localization (secretion) of pH-stat in proximal
3) Confidence 0.57 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787766 Disease Relevance 0.32 Pain Relevance 0.36
STAT proteins are then phosphorylated and translocated to the nucleus, which initiates transcription of growth hormone target proteins (Argetsinger et al 1993).
Localization (translocated) of STAT in nucleus
4) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.07 Pain Relevance 0.04
Thus, while CP-690,550 can inhibit cytokine activation pathways associated with JAK1, subtle differences in JAK or STAT utilization by specific receptors may influence inhibitor potency and selectivity.
Localization (utilization) of STAT associated with potency and cytokine
5) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.39
1 and IL-23R chain are associated with intracellular proteins of the Janus kinase (Jak) family to induce downstream signaling, resulting in a sequence of phosphorylation processes activating signal transducer and activator of transcription (STAT) molecules, namely STAT1, STAT3, STAT4, and STAT5, which translocate into the nucleus where they bind DNA in the promoter region of target genes.24
Localization (translocate) of STAT in nucleus
6) Confidence 0.06 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.34 Pain Relevance 0.08
The STAT proteins form homo- or heterodimers and translocate to the nucleus where they induce transcription of proinflammatory genes.
Localization (translocate) of STAT in nucleus
7) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.39 Pain Relevance 0.17
The STAT proteins then homo-or heterodimerize and translocate to the nucleus, where they bind to DNA and modulate gene expression.
Localization (translocate) of STAT in nucleus
8) Confidence 0.05 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.79 Pain Relevance 0.27
While phosphorylation of tyrosine residue 701 on STAT1 is an event essential for STAT dimerizaton and translocation, it neither is a required precursor to serine 727 phosphorylation nor a mediator of apoptosis [58-60].
Localization (translocation) of STAT associated with apoptosis
9) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.42 Pain Relevance 0

General Comments

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