INT100542

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 11.78
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppig) protein folding (Ppig) nucleus (Ppig)
cytoplasm (Ppig)
Anatomy Link Frequency
liver 3
CAR 1
Ppig (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 20 99.96 Very High Very High Very High
headache 2 99.92 Very High Very High Very High
Inflammation 50 99.76 Very High Very High Very High
Analgesic 1 97.12 Very High Very High Very High
Inflammatory response 10 84.84 Quite High
depression 80 83.64 Quite High
Migraine 1 80.00 Quite High
Inflammatory stimuli 20 42.40 Quite Low
Versed 4 39.20 Quite Low
drug abuse 2 29.12 Quite Low
Disease Link Frequency Relevance Heat
Headache 3 99.92 Very High Very High Very High
Infection 620 99.80 Very High Very High Very High
INFLAMMATION 80 99.76 Very High Very High Very High
Cerebral Malaria 50 99.56 Very High Very High Very High
Malaria 450 99.40 Very High Very High Very High
Gastrointestinal Disease 2 99.40 Very High Very High Very High
Sprains And Strains 150 99.20 Very High Very High Very High
Nicotine Addiction 136 98.60 Very High Very High Very High
Death 50 97.04 Very High Very High Very High
Stress 290 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of rutaecarpine on hepatic and renal cytochrome P450 (CYP)-dependent monooxygenase were studied in C57BL/6J mice.
Regulation (Effects) of CYP
1) Confidence 0.17 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.20 Pain Relevance 0.10
To assess the possible drug interactions, effects of methanol and aqueous extracts of E. rutaecarpa on drug-metabolizing enzymes, cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) were studied in C57BL/6J mice.
Spec (possible) Regulation (effects) of CYP
2) Confidence 0.17 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.20 Pain Relevance 0.10
CYP regulation is, in most cases, not dependent only on a specific nuclear factor, but requires a complex network of interacting factors (Waxman 1999).


Regulation (regulation) of CYP
3) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.56 Pain Relevance 0
However, CYP activities toward 7-ethoxycoumarin, benzphetamine, N-nitrosodimethylamine, erythromycin and nifedipine, and conjugation activities of UGT and GST were not affected.
Neg (not) Regulation (affected) of CYP
4) Confidence 0.12 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184732 Disease Relevance 0.16 Pain Relevance 0.08
To assess the possible herb-drug interaction, effects of S. flavescens extracts on hepatic cytochrome P450 (P450, CYP) enzymes were studied.
Regulation (effects) of CYP
5) Confidence 0.08 Published 2009 Journal J Ethnopharmacol Section Abstract Doc Link 19772910 Disease Relevance 0 Pain Relevance 0.10
We therefore studied expression of the aryl hydrocarbon receptor (AHR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), liver X receptor (LXR), and glucocorticoid receptor (GR) (Gibson et al. 2002; Tirona et al. 2003) for their established role in CYP gene regulation in BAL cells and BBs derived from smokers and nonsmokers.
Regulation (regulation) of CYP in CAR associated with nicotine addiction
6) Confidence 0.07 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.57 Pain Relevance 0
Modulation of CYP activities by malaria, therefore, is not necessarily associated with a terminal stage of an invariably lethal infection, because, on one side, it was not observed in mice (C57BL/6) developing a severe and deadly cerebral malaria, and, on the other side, it occurred near the parasitaemia peak in animals with non-lethal infections.
Regulation (Modulation) of CYP associated with malaria, cerebral malaria and infection
7) Confidence 0.07 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.19 Pain Relevance 0
It is of note that CYP activities remained almost unaltered in C57BL/6 mice infected with P.berghei, most of which developed severe neurological symptoms compatible with cerebral malaria.
Regulation (unaltered) of CYP associated with cerebral malaria
8) Confidence 0.07 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.02 Pain Relevance 0
Results from this study showed that up- and down-regulation of CYP activities during P.berghei and P.chabaudi infections occurred when parasitaemia rates were high.
Regulation (regulation) of CYP associated with infection
9) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.11 Pain Relevance 0.08
Changes of CYP activities in P. chabaudi- infected mice (non-lethal malaria)
Regulation (Changes) of CYP associated with malaria
10) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.35 Pain Relevance 0.04
Taken together, findings presented here suggested that high parasitaemia rate was a major clinical feature associated with infection-produced alterations of liver CYP activities regardless of whether infection further progressed toward the death (P.berghei) or cure (P.chabaudi) of malarious mice.
Regulation (alterations) of CYP in liver associated with death and infection
11) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.11 Pain Relevance 0
It is also unclear whether CYP activities are modulated during non-lethal malaria infections.
Spec (whether) Regulation (modulated) of CYP associated with malaria and infection
12) Confidence 0.03 Published 2010 Journal Malar J Section Abstract Doc Link PMC2858213 Disease Relevance 0.71 Pain Relevance 0.04
At any rate, data presented here demonstrated that liver CYP activities are modulated during murine lethal and non-lethal infections and it seems fair to think that this modulation of enzymes involved in drug metabolism also occurs in human falciparum malaria.


Regulation (modulated) of CYP in liver associated with malaria and infection
13) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.09 Pain Relevance 0.03
Several studies have shown that stimulation of host defense mechanisms against infections, as well as treatment with pro-inflammatory cytokines, modulate the expression and activity of cytochrome P450 enzymes (CYP), thereby modifying the kinetics of drugs and toxicants [1,2].
Regulation (modulate) of CYP associated with inflammation, infection and cytokine
14) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.63 Pain Relevance 0.10
The foregoing observation suggested that up- (CYP2a5) and down- (CYP1a and 2b) regulations of liver CYP activities during malaria infections do not seem to be associated with accumulation of haemozoin in the hepatic tissue.
Regulation (regulations) of CYP in liver associated with malaria and infection
15) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.20 Pain Relevance 0
In P.berghei-infected C57BL/6 mice CYP activities remained unaltered.
Regulation (unaltered) of CYP
16) Confidence 0.03 Published 2010 Journal Malar J Section Abstract Doc Link PMC2858213 Disease Relevance 0.70 Pain Relevance 0.03

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