INT100544

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 6.81
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp1) mitosis (Fabp1) transport (Fabp1)
nucleus (Fabp1) cytoplasm (Fabp1)
Anatomy Link Frequency
liver 7
plasma 2
adipose tissue 1
Fabp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 52 99.98 Very High Very High Very High
Inflammation 198 98.98 Very High Very High Very High
ischemia 126 98.78 Very High Very High Very High
Inflammatory response 54 98.68 Very High Very High Very High
imagery 3 97.88 Very High Very High Very High
alcohol 17 95.16 Very High Very High Very High
Nucleus accumbens 5 91.36 High High
Dopamine 11 90.64 High High
anesthesia 46 88.92 High High
Inflammatory stimuli 9 84.80 Quite High
Disease Link Frequency Relevance Heat
Injury 281 99.86 Very High Very High Very High
Obesity 6 99.36 Very High Very High Very High
INFLAMMATION 261 98.98 Very High Very High Very High
Cv Unclassified Under Development 126 98.78 Very High Very High Very High
Drug Dependence 15 98.68 Very High Very High Very High
Cv General 3 Under Development 6 97.72 Very High Very High Very High
Diabetes Mellitus 19 94.40 High High
Renal Disease 4 89.48 High High
Dyslipidemia /

Combined Dyslipidemia

4 88.92 High High
Alcohol Addiction 4 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients undergoing lower abdominal surgery, the mean L-FABP concentration remained below 15 ng/ml, underlining the effect of direct manipulation of the liver on the elevation of L-FABP plasma levels during liver surgery (Fig. 2).
Positive_regulation (elevation) of L-FABP in liver
1) Confidence 0.38 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.51 Pain Relevance 0.14
Surprisingly, we found no additional effect of organ transection or intermittent Pringle maneuver on these increased L-FABP and GST?
Neg (no) Positive_regulation (increased) of L-FABP
2) Confidence 0.38 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.89 Pain Relevance 0.18
By measuring concentration gradients across the intestines and the liver, we were able to show that the increased L-FABP levels during liver manipulation are exclusively due to L-FABP release from the liver.
Positive_regulation (increased) of L-FABP in liver
3) Confidence 0.38 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.51 Pain Relevance 0.16
By measuring concentration gradients across the intestines and the liver, we were able to show that the increased L-FABP levels during liver manipulation are exclusively due to L-FABP release from the liver.
Positive_regulation (due) of L-FABP in liver
4) Confidence 0.38 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.59 Pain Relevance 0.19
We were able to rule out the first two factors as potential causes of early hepatocyte injury since a similar increase of L-FABP plasma concentrations did not occur in patients undergoing lower intestinal surgery.
Positive_regulation (increase) of L-FABP in plasma associated with injury
5) Confidence 0.38 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.39 Pain Relevance 0.16
Intermittent Pringle maneuver (2 × 15 min ischemia and 5 min reperfusion) did not cause significant changes in arterial L-FABP or GST?
Positive_regulation (arterial) of L-FABP associated with ischemia
6) Confidence 0.28 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.70 Pain Relevance 0.17
L-FABP was specifically released from the liver (p < 0.0001 vs. zero) and removed from circulation by the kidneys (p < 0.0001 vs. zero)


Positive_regulation (removed) of L-FABP in liver
7) Confidence 0.28 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.12 Pain Relevance 0.03
Finally, we were able to rule out systemic inflammation as a leading cause of hepatocellular injury since L-FABP peak levels were reached already before the onset of the inflammatory response.
Positive_regulation (reached) of L-FABP associated with inflammatory response, inflammation and injury
8) Confidence 0.26 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 1.01 Pain Relevance 0.30
By elimination of other potential causes, it thus must be concluded that increasing L-FABP levels occurs during and due to liver manipulation in patients undergoing liver resection.
Positive_regulation (increasing) of L-FABP in liver
9) Confidence 0.26 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.34 Pain Relevance 0.11
Persistently increased urinary NGAL and L-FABP may suggest renotubular damage in this population.


Positive_regulation (increased) of L-FABP
10) Confidence 0.21 Published 2009 Journal Adv Med Sci Section Body Doc Link 19875355 Disease Relevance 0.08 Pain Relevance 0
agonist-upregulated fatty acid binding protein(FABP3) mRNA in adipose tissue and PPAR?
Positive_regulation (upregulated) of fatty acid binding protein in adipose tissue associated with obesity and agonist
11) Confidence 0.21 Published 2004 Journal BMC Pharmacol Section Abstract Doc Link PMC526775 Disease Relevance 0.28 Pain Relevance 0.30
METHODS: Serum, urinary NGAL, cystatin C, urinary kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP) were evaluated before and 2, 4, 8, 24, and 48 hours after cardiac catheterization using commercially available kits.
Positive_regulation (evaluated) of L-FABP in liver
12) Confidence 0.17 Published 2009 Journal Ren Fail Section Body Doc Link 20030526 Disease Relevance 0.27 Pain Relevance 0
METHODS: Serum, urinary NGAL, cystatin C, urinary kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP) were evaluated before and 2, 4, 8, 24, and 48 hours after cardiac catheterization using commercially available kits.
Positive_regulation (evaluated) of liver-type fatty acid binding protein in liver
13) Confidence 0.15 Published 2009 Journal Ren Fail Section Body Doc Link 20030526 Disease Relevance 0.27 Pain Relevance 0
Exercise-induced increases in plasma markers of purine catabolism (hypoxanthine, xanthine oxidase, and serum uric acid) and circulating cytosolic proteins (myoglobin, fatty acid-binding protein, and creatine kinase) were significantly (P < or = 0.05) attenuated by LCLT.
Positive_regulation (increases) of fatty acid-binding protein in plasma
14) Confidence 0.11 Published 2002 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11788381 Disease Relevance 0.07 Pain Relevance 0.14
MATERIAL AND METHODS: We measured serum NGAL, urinary NGAL and L-FABP using commercially available kits before and after 2, 4, 12, 24 and 48 hours following PCI in 25 patients.
Positive_regulation (urinary) of L-FABP
15) Confidence 0.10 Published 2009 Journal Adv Med Sci Section Body Doc Link 19875355 Disease Relevance 0.10 Pain Relevance 0
Peroxiredoxin, creatine kinase, fatty acid binding protein are some of the proteins that are upregulated in chronic alcoholic patients.
Positive_regulation (upregulated) of fatty acid binding protein
16) Confidence 0.08 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.59 Pain Relevance 0.75

General Comments

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