INT100548

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Context Info
Confidence 0.29
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.56
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelets 2
plasma 1
T cell 1
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 14 100.00 Very High Very High Very High
aspirin 5 99.84 Very High Very High Very High
metalloproteinase 5 99.34 Very High Very High Very High
Inflammation 155 94.64 High High
Migraine 2 50.00 Quite Low
Arthritis 37 49.52 Quite Low
Kinase C 4 17.24 Low Low
Nicotine 40 9.84 Low Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 11 100.00 Very High Very High Very High
Nicotine Addiction 732 99.86 Very High Very High Very High
INFLAMMATION 183 94.64 High High
Periodontal Disease 44 93.60 High High
Disease 163 92.16 High High
Headache 2 89.76 High High
Adhesions 376 88.12 High High
Mucocutaneous Lymph Node Syndrome 50 86.24 High High
Thrombosis Related Under Development 4 85.84 High High
Peripheral Arterial Disease 4 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased surface of P-selectin on platelets is not affected by aspirin administration (2 weeks at 100 mg/day) [112].


Regulation (affected) of P-selectin in platelets associated with aspirin
1) Confidence 0.29 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.96 Pain Relevance 0.21
The increased surface of P-selectin on platelets is not affected by aspirin administration (2 weeks at 100 mg/day) [112].


Neg (not) Regulation (affected) of P-selectin in platelets associated with aspirin
2) Confidence 0.29 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.96 Pain Relevance 0.21
OBJECTIVE: To explore the effect of Composite Salviae Dropping Pill (CSDP) on the level of alpha-granule membrane protein-140 (GMP-140) in unstable angina pectoris (UAP).
Regulation (effect) of GMP-140 associated with angina
3) Confidence 0.20 Published 2000 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 11789221 Disease Relevance 0.35 Pain Relevance 0.35
However, there is some evidence to suggest that smoking could influence sP-selectin levels.
Regulation (influence) of sP-selectin associated with nicotine addiction
4) Confidence 0.15 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.61 Pain Relevance 0.03
However, there is some evidence to suggest that smoking could influence sP-selectin levels.
Regulation (influence) of sP-selectin associated with nicotine addiction
5) Confidence 0.15 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.61 Pain Relevance 0.03
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Regulation (regulated) of P-Selectin in T cell associated with metalloproteinase
6) Confidence 0.11 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.79 Pain Relevance 0.16
Changes of PMAM GP II b/III a(CD41) and P-selectin (CD62P) were observed by flow-cytometry and compared with those in healthy persons.
Regulation (Changes) of CD62P
7) Confidence 0.11 Published 2001 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12575374 Disease Relevance 0.18 Pain Relevance 0
[The clinical significance of changes in plasma levels of alpha-granule membrane protein and D-dimer in patients with unstable angina].
Regulation (changes) of alpha-granule membrane protein in plasma associated with angina
8) Confidence 0.06 Published 1999 Journal Zhonghua Nei Ke Za Zhi Section Title Doc Link 11798690 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

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