INT100549

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.17
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
endothelial cells 1
T cell 1
neutrophils 1
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 100.00 Very High Very High Very High
Inflammation 38 98.76 Very High Very High Very High
rheumatoid arthritis 10 96.36 Very High Very High Very High
cytokine 6 96.24 Very High Very High Very High
Thermal hyperalgesia 4 96.00 Very High Very High Very High
Arthritis 39 92.12 High High
antagonist 1 91.64 High High
Hyperalgesia 6 82.96 Quite High
Kinase C 1 75.00 Quite High
Pain 2 66.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
Cold Sores 1 99.82 Very High Very High Very High
INFLAMMATION 41 98.76 Very High Very High Very High
Rheumatoid Arthritis 12 96.36 Very High Very High Very High
Hyperalgesia 11 96.00 Very High Very High Very High
Disease 69 94.68 High High
Mucocutaneous Lymph Node Syndrome 50 88.76 High High
Increased Venous Pressure Under Development 11 88.72 High High
Sickle Cell Anemia 2 85.32 High High
Cancer 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this report we demonstrate that the flow adherence of sickle cells to thrombin-treated human vascular endothelial cells also uses P-selectin and that this component of adhesion is inhibited by unfractionated heparin.
Negative_regulation (inhibited) of P-selectin in endothelial cells associated with adhesions
1) Confidence 0.43 Published 2002 Journal Blood Section Abstract Doc Link 12393591 Disease Relevance 0.91 Pain Relevance 0.07
Moreover, the GMP-140 level in the CSDP group was reduced significantly as compared with the control group, and to approach the level of normal (P > 0.05), while in the control group, it was higher as compared with the normal control (P < 0.05).
Negative_regulation (reduced) of GMP-140
2) Confidence 0.14 Published 2000 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 11789221 Disease Relevance 0.13 Pain Relevance 0
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Negative_regulation (inhibitor) of P-Selectin in T cell associated with metalloproteinase
3) Confidence 0.08 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.91 Pain Relevance 0.21
Reduction in expression of endothelial adhesion molecules (ICAM-1, VCAM-1, E-selectin and P-selectin) also contributes to the anti-inflammatory effect (Seljeflot et al 2002).
Negative_regulation (Reduction) of P-selectin associated with inflammation and adhesions
4) Confidence 0.02 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.83 Pain Relevance 0.26
In the case of compound 2, it has been isolated from several terrestrial and marine sources, as from leaves of Byrsonima crassifolia [21,26], from the brown seaweeds Ishige okamurai and Sargassum parvivesiculosum [25,27], from the green algae Caulerpa racemosa and Dictyochloris fragrans with notable selective antiviral activity against HSV-2 and a P-selectin receptor inhibitor [16,28].
Negative_regulation (inhibitor) of P-selectin associated with cold sores
5) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866487 Disease Relevance 0.10 Pain Relevance 0
The role of neutrophils was determined through use of the selectin inhibitor, fucoidan.
Negative_regulation (inhibitor) of selectin in neutrophils
6) Confidence 0.01 Published 2009 Journal Pain Section Abstract Doc Link 19231080 Disease Relevance 1.28 Pain Relevance 0.92

General Comments

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