INT10056

Context Info Confidence 0.59 First Reported 1980 Last Reported 2011 Negated 7 Speculated 1 Reported most in Abstract Documents 77 Total Number 80 Disease Relevance 36.99 Pain Relevance 16.80

cytosol (Fabp6) cytoplasm (Fabp6)

Anatomy Link Frequency blood 7 anterior 5 plasma 4 lobe 3 sympathetic 2 Fabp6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 24 100.00 Clonidine 57 99.98 anesthesia 41 99.98 Enkephalin 23 99.96 noradrenaline 13 99.90 narcan 12 99.84 Catecholamine 5 99.58 Cannabinoid 9 99.56 Intracerebroventricular 4 99.14 Kappa opioid receptor 5 99.02

Disease Link Frequency Relevance Heat Hypertension 632 100.00 Diabetes Mellitus 416 100.00 Pressure And Volume Under Development 27 100.00 Ganglion Cysts 25 99.76 Nociception 28 99.68 Hypotension 14 99.58 Stress 67 99.46 Sprains And Strains 168 98.68 Anxiety Disorder 10 98.36 Attention Deficit Hyperactivity Disorder 151 97.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The current study tested the hypothesis that the antihypertensive effect of chronic systemic administration of guanabenz (0.24 micrograms/kg/min, IV) is enhanced in SHR-S maintained on a high (8%) NaCl diet than in control rats on a normal (1% NaCl) diet.

Positive_regulation (enhanced) of SHR-S

1) Confidence 0.59 Published 1989 Journal Am. J. Hypertens. Section Abstract Doc Link 2757799 Disease Relevance 0.31 Pain Relevance 0.09

Capillary hematocrit and viscosity were not elevated in the SHR.

Neg (not) Positive_regulation (elevated) of SHR in Capillary

2) Confidence 0.58 Published 1983 Journal Microvasc. Res. Section Abstract Doc Link 6843369 Disease Relevance 0.24 Pain Relevance 0

The lower pressure limit of autoregulation (LPLAR) shifted upward as the blood pressure increased in the SHR with age; it did not shift in the WKY.

Positive_regulation (increased) of SHR in blood

3) Confidence 0.58 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 4034536 Disease Relevance 0.49 Pain Relevance 0.08

Both are augmented in SHR.

Positive_regulation (augmented) of SHR

4) Confidence 0.57 Published 2001 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 11710757 Disease Relevance 0.75 Pain Relevance 0.17

Our previous studies demonstrated that high dietary NaCl intake causes increases in blood pressure and plasma norepinephrine (NE) levels and a decrease in NE release associated with local upregulation of alpha 2-adrenoceptor number in the anterior hypothalamic area (AHA) of NaCl-sensitive spontaneously hypertensive rats (SHR-S).

Positive_regulation (upregulation) of SHR-S in blood associated with pressure and volume under development and hypertension

5) Confidence 0.49 Published 1989 Journal Am. J. Hypertens. Section Abstract Doc Link 2757799 Disease Relevance 0.27 Pain Relevance 0.10

DZ increased flow and reduced resistance in the coronary and skeletal muscle circulations of SHR to a greater extent than in WKY.

Positive_regulation (increased) of SHR in skeletal muscle

6) Confidence 0.49 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2422460 Disease Relevance 0.40 Pain Relevance 0

Our previous studies demonstrated that (a) dietary Ca2+ supplementation prevents the rise in blood pressure, activation of sympathetic outflow, and reductions in anterior hypothalamic norepinephrine (NE) content and release induced in NaCl-sensitive spontaneous hypertensive rats (SHR-S) by dietary NaCl loading; and (b) stimulation of alpha 2-adrenoceptors by microinjection of clonidine into the anterior hypothalamic area (AHA) results in an exaggerated depressor response in SHR-S fed a high NaCl diet as compared with SHR-S on a basal diet.

Positive_regulation (induced) of SHR in anterior associated with pressure and volume under development, hypertension and clonidine

7) Confidence 0.48 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468929 Disease Relevance 0.27 Pain Relevance 0.15

We have previously shown that dietary NaCl supplementation increases blood pressure and sympathetic nervous system activity in association with decreased norepinephrine release and increased alpha 2-adrenergic receptor number in the anterior hypothalamic area of salt-sensitive spontaneously hypertensive rats (SHR-S) but not in salt-resistant spontaneously hypertensive rats (SHR-R) or Wistar-Kyoto (WKY) rats.

Positive_regulation (increases) of SHR-S in anterior associated with hypertension

8) Confidence 0.47 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.34 Pain Relevance 0.29

We have previously shown that dietary NaCl supplementation increases blood pressure and sympathetic nervous system activity in association with decreased norepinephrine release and increased alpha 2-adrenergic receptor number in the anterior hypothalamic area of salt-sensitive spontaneously hypertensive rats (SHR-S) but not in salt-resistant spontaneously hypertensive rats (SHR-R) or Wistar-Kyoto (WKY) rats.

Positive_regulation (increases) of SHR-R in anterior associated with hypertension

9) Confidence 0.47 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.35 Pain Relevance 0.31

The experiments with the SHR were conducted in parallel with age matched SD rats. 2.

Positive_regulation (conducted) of SHR

10) Confidence 0.42 Published 1991 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1782722 Disease Relevance 0.23 Pain Relevance 0

These results suggest that the release of 5-hydroxytryptamine from adrenergic nerve endings by periarterial nerve stimulation is enhanced in the mesenteric vascular bed of the SHR.

Positive_regulation (enhanced) of SHR in nerve

11) Confidence 0.42 Published 1987 Journal Hypertension Section Abstract Doc Link 3623684 Disease Relevance 0.07 Pain Relevance 0.13

Further, acute microinjection of clonidine into the anterior hypothalamic area produced depressor responses that were augmented by high salt feeding in SHR-S but not in SHR-R or WKY rats.

Positive_regulation (augmented) of SHR-S in anterior associated with clonidine

12) Confidence 0.41 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.40 Pain Relevance 0.41

Further, acute microinjection of clonidine into the anterior hypothalamic area produced depressor responses that were augmented by high salt feeding in SHR-S but not in SHR-R or WKY rats.

Positive_regulation (augmented) of SHR-R in anterior associated with clonidine

13) Confidence 0.41 Published 1991 Journal Hypertension Section Abstract Doc Link 1885231 Disease Relevance 0.41 Pain Relevance 0.41

The purpose of this investigation is to test the hypothesis that capillary pressure gradients are elevated in spontaneously hypertensive rats (SHR) and to determine the mechanism for the elevation.

Positive_regulation (elevated) of SHR in capillary associated with hypertension

14) Confidence 0.39 Published 1983 Journal Microvasc. Res. Section Abstract Doc Link 6843369 Disease Relevance 0.17 Pain Relevance 0.09

Resting hindlimb flow, elevated in the SHR at 6 weeks, was also elevated at the LPLAR.

Positive_regulation (elevated) of SHR in hindlimb

15) Confidence 0.39 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 4034536 Disease Relevance 0.50 Pain Relevance 0.07

Resting hindlimb flow, elevated in the SHR at 6 weeks, was also elevated at the LPLAR.

Positive_regulation (elevated) of SHR in hindlimb

16) Confidence 0.39 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 4034536 Disease Relevance 0.51 Pain Relevance 0.07

Arteriolar wall-to-lumen ratio was not elevated in the SHR at any time.

Neg (not) Positive_regulation (elevated) of SHR in lumen

17) Confidence 0.39 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7114235 Disease Relevance 0.47 Pain Relevance 0.07

Examination of the jejunal arteries from these rats at 12 weeks of age following normal development, or 8 weeks of hypertension development, or 8 and 12 weeks of diabetes, showed that increased innervation occurred in the SHR under all conditions, and in the diabetic rats after 8 weeks of diabetes.

Positive_regulation (occurred) of SHR associated with diabetes mellitus and hypertension

18) Confidence 0.38 Published 1985 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 4005709 Disease Relevance 1.20 Pain Relevance 0.18

Similar to adult rats, cardiovascular and nociceptive responses were augmented in prehypertensive SHR than age-matched WKY.

Positive_regulation (augmented) of SHR associated with nociception

19) Confidence 0.38 Published 2001 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 11710757 Disease Relevance 0.70 Pain Relevance 0.15

As pointed out by Taylor et al., the exaggerated fight-or-flight stress responses and sympathetic activation in SHR may be related to their abnormal nociceptive phenotype [7].

Positive_regulation (activation) of SHR in sympathetic associated with nociception and stress

20) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1802084 Disease Relevance 0.82 Pain Relevance 0.72

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