INT10056
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The current study tested the hypothesis that the antihypertensive effect of chronic systemic administration of guanabenz (0.24 micrograms/kg/min, IV) is enhanced in SHR-S maintained on a high (8%) NaCl diet than in control rats on a normal (1% NaCl) diet. | |||||||||||||||
| |||||||||||||||
|
Capillary hematocrit and viscosity were not elevated in the SHR. | |||||||||||||||
| |||||||||||||||
|
The lower pressure limit of autoregulation (LPLAR) shifted upward as the blood pressure increased in the SHR with age; it did not shift in the WKY. | |||||||||||||||
| |||||||||||||||
|
Both are augmented in SHR. | |||||||||||||||
| |||||||||||||||
|
Our previous studies demonstrated that high dietary NaCl intake causes increases in blood pressure and plasma norepinephrine (NE) levels and a decrease in NE release associated with local upregulation of alpha 2-adrenoceptor number in the anterior hypothalamic area (AHA) of NaCl-sensitive spontaneously hypertensive rats (SHR-S). | |||||||||||||||
| |||||||||||||||
|
DZ increased flow and reduced resistance in the coronary and skeletal muscle circulations of SHR to a greater extent than in WKY. | |||||||||||||||
| |||||||||||||||
|
Our previous studies demonstrated that (a) dietary Ca2+ supplementation prevents the rise in blood pressure, activation of sympathetic outflow, and reductions in anterior hypothalamic norepinephrine (NE) content and release induced in NaCl-sensitive spontaneous hypertensive rats (SHR-S) by dietary NaCl loading; and (b) stimulation of alpha 2-adrenoceptors by microinjection of clonidine into the anterior hypothalamic area (AHA) results in an exaggerated depressor response in SHR-S fed a high NaCl diet as compared with SHR-S on a basal diet. | |||||||||||||||
| |||||||||||||||
|
We have previously shown that dietary NaCl supplementation increases blood pressure and sympathetic nervous system activity in association with decreased norepinephrine release and increased alpha 2-adrenergic receptor number in the anterior hypothalamic area of salt-sensitive spontaneously hypertensive rats (SHR-S) but not in salt-resistant spontaneously hypertensive rats (SHR-R) or Wistar-Kyoto (WKY) rats. | |||||||||||||||
| |||||||||||||||
|
We have previously shown that dietary NaCl supplementation increases blood pressure and sympathetic nervous system activity in association with decreased norepinephrine release and increased alpha 2-adrenergic receptor number in the anterior hypothalamic area of salt-sensitive spontaneously hypertensive rats (SHR-S) but not in salt-resistant spontaneously hypertensive rats (SHR-R) or Wistar-Kyoto (WKY) rats. | |||||||||||||||
| |||||||||||||||
|
The experiments with the SHR were conducted in parallel with age matched SD rats. 2. | |||||||||||||||
| |||||||||||||||
|
These results suggest that the release of 5-hydroxytryptamine from adrenergic nerve endings by periarterial nerve stimulation is enhanced in the mesenteric vascular bed of the SHR. | |||||||||||||||
| |||||||||||||||
|
Further, acute microinjection of clonidine into the anterior hypothalamic area produced depressor responses that were augmented by high salt feeding in SHR-S but not in SHR-R or WKY rats. | |||||||||||||||
| |||||||||||||||
|
Further, acute microinjection of clonidine into the anterior hypothalamic area produced depressor responses that were augmented by high salt feeding in SHR-S but not in SHR-R or WKY rats. | |||||||||||||||
| |||||||||||||||
|
The purpose of this investigation is to test the hypothesis that capillary pressure gradients are elevated in spontaneously hypertensive rats (SHR) and to determine the mechanism for the elevation. | |||||||||||||||
| |||||||||||||||
|
Resting hindlimb flow, elevated in the SHR at 6 weeks, was also elevated at the LPLAR. | |||||||||||||||
| |||||||||||||||
|
Resting hindlimb flow, elevated in the SHR at 6 weeks, was also elevated at the LPLAR. | |||||||||||||||
| |||||||||||||||
|
Arteriolar wall-to-lumen ratio was not elevated in the SHR at any time. | |||||||||||||||
| |||||||||||||||
|
Examination of the jejunal arteries from these rats at 12 weeks of age following normal development, or 8 weeks of hypertension development, or 8 and 12 weeks of diabetes, showed that increased innervation occurred in the SHR under all conditions, and in the diabetic rats after 8 weeks of diabetes. | |||||||||||||||
| |||||||||||||||
|
Similar to adult rats, cardiovascular and nociceptive responses were augmented in prehypertensive SHR than age-matched WKY. | |||||||||||||||
| |||||||||||||||
|
As pointed out by Taylor et al., the exaggerated fight-or-flight stress responses and sympathetic activation in SHR may be related to their abnormal nociceptive phenotype [7]. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.