INT100566

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.22
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
dorsal 1
neurons 1
striatum 1
forebrain 1
amygdala 1
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 19 99.68 Very High Very High Very High
nMDA receptor 29 99.60 Very High Very High Very High
Hippocampus 37 98.88 Very High Very High Very High
Morphine 27 98.00 Very High Very High Very High
opioid receptor 4 93.96 High High
agonist 4 93.32 High High
antagonist 12 93.12 High High
Glutamate receptor 16 89.40 High High
nMDA receptor antagonist 5 85.44 High High
drug abuse 6 82.24 Quite High
Disease Link Frequency Relevance Heat
Psychosis 12 98.32 Very High Very High Very High
Schizophrenia 15 93.40 High High
Nociception 1 88.24 High High
Urological Neuroanatomy 3 87.40 High High
Drug Dependence 12 82.24 Quite High
Depression 4 75.44 Quite High
Diabetic Nephropathy 1 75.00 Quite High
Nervous System Injury 5 66.08 Quite High
Hyperalgesia 1 55.60 Quite High
Cognitive Disorder 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMPA receptor subunits GluR1, -R2, -R3 and -R4 mRNAs were expressed in a large number of gracile nucleus neurons.
Transcription (expressed) of AMPA in neurons
1) Confidence 0.25 Published 2002 Journal Pain Section Abstract Doc Link 11790478 Disease Relevance 0.54 Pain Relevance 0.69
In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3.
Transcription (expression) of AMPA in striatum associated with hippocampus, amygdala and morphine
2) Confidence 0.20 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.73
Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization.
Transcription (expression) of AMPA in amygdala associated with hippocampus, amygdala and morphine
3) Confidence 0.20 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.56
In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3.
Transcription (expression) of AMPA in prefrontal associated with hippocampus, amygdala and morphine
4) Confidence 0.07 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.73
Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization.
Transcription (expression) of AMPA in dorsal associated with hippocampus, amygdala and morphine
5) Confidence 0.07 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.56
The present study provides evidence that repeated intermittent MDMA administration causes pronounced changes in mRNA expression of certain glutamatergic NMDA and AMPA receptor subunits, metabotropic receptors and transporters in the forebrain cortex, CPU and the hypothalamus.
Transcription (expression) of AMPA in forebrain
6) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.15
Glutamatergic mRNA expression of AMPA receptor subunits was also affected by repeated intermittent MDMA administration.
Transcription (expression) of AMPA
7) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.68 Pain Relevance 0.50
In the CPU, MDMA high significantly enhanced mRNA levels of the AMPA subunit GluR3, NMDA subunits NR2A and NR2B, Figure 1C.
Transcription (levels) of AMPA
8) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0

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