INT100573

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 2.09
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
Anatomy Link Frequency
Schwann cells 3
nerve 2
plasma 1
liver 1
IEL 1
Lpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 99.12 Very High Very High Very High
Peripheral nervous system 20 57.20 Quite High
spinal inflammation 4 50.00 Quite Low
cerebral cortex 10 40.56 Quite Low
anesthesia 14 11.92 Low Low
Sciatic nerve 30 5.00 Very Low Very Low Very Low
Glutamate 20 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 70 99.24 Very High Very High Very High
Porphyria 12 83.12 Quite High
Injury 20 81.44 Quite High
Stress 40 81.20 Quite High
Pancreatitis 3 53.28 Quite High
Low Back Pain 4 50.00 Quite Low
Alcoholic Pancreatitis 3 50.00 Quite Low
Hypertrophy 16 5.00 Very Low Very Low Very Low
Body Weight 16 5.00 Very Low Very Low Very Low
Toxicity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of lipoprotein lipase was increased in the high dose groups from day 3, and this is also the time point at which changes in the lipid species present were first detected by GC-MS.
Gene_expression (Expression) of lipoprotein lipase
1) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0
PLS demonstrated a correlation between the CH2 resonance of plasma lipoproteins and LPL expression.
Gene_expression (expression) of LPL in plasma
2) Confidence 0.53 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.16 Pain Relevance 0.04
LPL is not normally expressed in liver tissue of adult rats.
Neg (not) Gene_expression (expressed) of LPL in liver
3) Confidence 0.46 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.16 Pain Relevance 0.04
LPL is found in the endothelial cells lining capillaries of tissues and hydrolyses triglycerides from lipoproteins circulating in the plasma to release fatty acids which can be taken up by the tissue.
Gene_expression (found) of LPL in endothelial cells
4) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.14 Pain Relevance 0.05
Here, we have applied a similar method to elucidate the expression of LPL receptor family genes in TSCs and compared the expression between TSCs and MSCs.
Gene_expression (expression) of LPL
5) Confidence 0.37 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.20 Pain Relevance 0
Weiner and Chun studied the expression of LPL receptors in Schwann cells (SC) in vivo and in vitro using total RNA by Northern blot analysis, and reported that LPA1 was expressed at high level by SCs in vivo and in vitro, whereas S1P1 was only expressed in SCs in vivo.
Gene_expression (expression) of LPL in Schwann cells
6) Confidence 0.37 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.13 Pain Relevance 0
Other types of LPL receptor genes, including LPA1, S1P2, S1P3, and S1P4, were expressed in both types of Schwann cells.
Gene_expression (expressed) of LPL in Schwann cells
7) Confidence 0.37 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0 Pain Relevance 0
Considering the fact that MSCs and TSCs behave differently after nerve injury, it would be worth studying changes of expression of each member of LPL gene family after nerve injury.
Gene_expression (expression) of LPL in nerve associated with nervous system injury
8) Confidence 0.37 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.32 Pain Relevance 0
None of the LPL receptor family genes showed MSC-specific expression.
Gene_expression (expression) of LPL
9) Confidence 0.32 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0 Pain Relevance 0
In conclusion, we studied the differential expression of LPL receptor gene family in TSCs and MSCs at single cell-based RT-PCR and found that LPA3 is specifically expressed in TSCs as confirmed by in situ hybridization.
Gene_expression (expression) of LPL
10) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.27 Pain Relevance 0
This differential expression of LPL receptors in TSCs and MSCs may underlie the behavior of each type of Schwann cells after nerve injury.



Gene_expression (expression) of LPL in nerve associated with nervous system injury
11) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.27 Pain Relevance 0
Other types of LPL receptor genes, including LPA1, S1P2, S1P3, S1P4, were expressed in both types of Schwann cells.
Gene_expression (expressed) of LPL in Schwann cells
12) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828080 Disease Relevance 0.07 Pain Relevance 0
In order to elucidate the molecular characteristics of TSCs when compared to MSCs, we have studied the expressions of LPL receptors by single cell RT-PCR and in situ hybridization.


Gene_expression (expressions) of LPL
13) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828080 Disease Relevance 0.22 Pain Relevance 0.03
By using our previously reported method of selectively and efficiently collecting TSCs, we have analyzed the difference in expression patterns of lysophospholipid (LPL) receptor genes (LPA1, LPA2, LPA3, S1P1, S1P2, S1P3, S1P4, and S1P5) between TSCs and myelinating Schwann cells (MSCs).
Spec (analyzed) Gene_expression (expression) of LPL in TSCs
14) Confidence 0.25 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828080 Disease Relevance 0.09 Pain Relevance 0
PSTI, LPL, PRSS1, and CFTR genes presented no association with chronic alcoholic pancreatitis.
Neg (no) Gene_expression (presented) of LPL
15) Confidence 0.07 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0.05 Pain Relevance 0
RESULTS: In situ no differences were observed in alphaEbeta7 and alpha4beta7 integrin expression in isolated IEL and LPL, whether determined by flow cytometry or by immunohistochemical staining.
Gene_expression (expression) of LPL in LPL
16) Confidence 0.03 Published 2001 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11791640 Disease Relevance 0 Pain Relevance 0
RESULTS: In situ no differences were observed in alphaEbeta7 and alpha4beta7 integrin expression in isolated IEL and LPL, whether determined by flow cytometry or by immunohistochemical staining.
Gene_expression (expression) of LPL in IEL
17) Confidence 0.01 Published 2001 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11791640 Disease Relevance 0 Pain Relevance 0

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