INT100586

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.18
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
thymocytes 2
plasma 1
spleen 1
thymus 1
Il2rb (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 24 99.58 Very High Very High Very High
Morphine 8 97.72 Very High Very High Very High
cytokine 33 84.12 Quite High
tolerance 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 39 100.00 Very High Very High Very High
Pulmonary Disease 60 97.36 Very High Very High Very High
Apoptosis 10 97.28 Very High Very High Very High
Cancer 5 95.44 Very High Very High Very High
Encephalitis 15 94.72 High High
Disease 35 94.56 High High
Targeted Disruption 9 92.04 High High
Rabies Virus Infection 2 84.48 Quite High
Cold Sores 1 74.16 Quite High
Death 14 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oncomice thymocytes from different experimental groups released less sIL-2R than FVB thymocytes.
Localization (released) of sIL-2R in thymocytes
1) Confidence 0.15 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.24 Pain Relevance 0.39
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice spleen and thymus cells depended on the presence of the oncogene product, on the in vivo pretreatment with cocaine, or on the in vitro treatment with cocaine or morphine.
Localization (release) of sIL-2R in thymus associated with morphine and cocaine
2) Confidence 0.15 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.26 Pain Relevance 0.26
Oncomice thymocytes cultured in the presence of Con A and cocaine showed a diminished release of sIL-2R and a lower secretion of IFN-gamma, a phenomenon not observed in FVB thymocytes.
Localization (release) of sIL-2R in thymocytes associated with cocaine
3) Confidence 0.15 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.23 Pain Relevance 0.41
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice spleen and thymus cells depended on the presence of the oncogene product, on the in vivo pretreatment with cocaine, or on the in vitro treatment with cocaine or morphine.
Localization (release) of sIL-2R in spleen associated with morphine and cocaine
4) Confidence 0.05 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.26 Pain Relevance 0.26
FasL and IL-2R were upregulated in the beginning of infection and deceased further.
Localization (deceased) of IL-2R associated with infection
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 1.01 Pain Relevance 0.11
Confirmatory studies specifically examining plasma IL-2, IL-2R and eotaxin-1 were conducted on an additional 17 stable and 6 rapidly progressive COPD subjects.
Localization (examining) of IL-2R in plasma associated with pulmonary disease
6) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2785783 Disease Relevance 1.18 Pain Relevance 0.21

General Comments

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