INT100591

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.51
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnip3) Golgi apparatus (Kcnip3) endoplasmic reticulum (Kcnip3)
intracellular (Kcnip3) DNA binding (Kcnip3) cytoplasm (Kcnip3)
Kcnip3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
neuralgia 5 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
long-term potentiation 40 99.36 Very High Very High Very High
nMDA receptor 106 99.16 Very High Very High Very High
depression 62 99.04 Very High Very High Very High
Lasting pain 5 98.92 Very High Very High Very High
Glutamate receptor 4 93.28 High High
Hippocampus 24 90.32 High High
Disease Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
Depression 62 99.04 Very High Very High Very High
Nociception 8 97.52 Very High Very High Very High
Targeted Disruption 43 92.04 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 84.64 Quite High
Neuropathic Pain 3 83.88 Quite High
Inflammatory Pain 1 80.40 Quite High
Necrosis 1 75.32 Quite High
Cancer 1 74.96 Quite High
Repression 2 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are needed to address the differential modulation of DREAM on hippocampal LTP and LTD.
Regulation (modulation) of DREAM associated with depression and long-term potentiation
1) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.94 Pain Relevance 0.87
Since DREAM nuclear repressor activity appears not to be responsible for the decrease in NMDA receptor function, we next investigated whether DREAM could directly interact with NMDA receptor subunits or interfere in the interaction of the receptor with docking proteins known to participate in receptor functions.
Spec (appears) Regulation (responsible) of DREAM associated with nmda receptor
2) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.12 Pain Relevance 0.58
This does not appear to be directly correlated with IL-10's regulation of DREAM, a transcriptional regulator of prodynorphin synthesis.
Regulation (regulation) of DREAM
3) Confidence 0.37 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12799032 Disease Relevance 0.67 Pain Relevance 0.33
DREAM is a critical transcriptional repressor for pain modulation.
Regulation (modulation) of DREAM associated with pain and enkephalin
4) Confidence 0.22 Published 2002 Journal Cell Section Title Doc Link 11792319 Disease Relevance 0.70 Pain Relevance 1.39

General Comments

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