INT100597

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
RPL21P132 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 100.00 Very High Very High Very High
cytokine 5 78.52 Quite High
Inflammatory mediators 1 61.28 Quite High
glial activation 1 50.04 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 3 99.56 Very High Very High Very High
Neurodegenerative Disease 2 91.08 High High
INFLAMMATION 2 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since microglial COX-2 expression and PGE(2) synthesis are increased in human and experimental prion diseases, we investigated the effects of the NSAIDs indomethacin and BF389, an experimental COX-2 selective inhibitor, on the PrP105-132-induced microglial IL-6 and TNF-alpha synthesis in vitro.
Spec (investigated) Regulation (effects) of PrP105-132 Positive_regulation (induced) of IL-6 associated with creutzfeldt jakob disease and cinod
1) Confidence 0.01 Published 2002 Journal Brain Res. Section Abstract Doc Link 11792368 Disease Relevance 0.45 Pain Relevance 0.53

General Comments

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