INT100598

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL6) Golgi apparatus (PRNP) endoplasmic reticulum (PRNP)
cytoplasm (PRNP) extracellular space (IL6) extracellular region (IL6)
Anatomy Link Frequency
PGE2 2
PRNP (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 93.48 High High
cytokine 5 75.00 Quite High
Inflammatory mediators 1 46.76 Quite Low
glial activation 1 35.52 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 3 84.60 Quite High
Neurodegenerative Disease 2 76.56 Quite High
INFLAMMATION 2 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated.
PrP Positive_regulation (induced) of Gene_expression (synthesis) of IL-6 in PGE2
1) Confidence 0.40 Published 2002 Journal Brain Res. Section Abstract Doc Link 11792368 Disease Relevance 0.23 Pain Relevance 0.40

General Comments

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