INT10060

Context Info Confidence 0.42 First Reported 1992 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.51 Pain Relevance 0.22

transport (MB)

Anatomy Link Frequency plasma 2 skeletal muscle tissue 1 thigh 1 MB (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 29 88.60 dysesthesia 1 77.16 Pain 14 71.76 cytokine 4 59.56 Angina 35 45.04 Inflammation 19 5.00 cocaine 6 5.00 metalloproteinase 5 5.00 alcohol 3 5.00 withdrawal 3 5.00

Disease Link Frequency Relevance Heat Acute Renal Failure 25 98.20 Rhabdomyolysis 101 97.72 Myalgia 11 95.52 Acute Coronary Syndrome 70 94.84 Renal Failure 19 94.56 Myocardial Infarction 46 91.84 Hyperkalemia 6 91.24 Hypercalcemia 1 88.96 Coronary Artery Disease 26 88.60 Pressure And Volume Under Development 3 88.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Twelve hours after admission, diagnostic performance was further improved for all CK and CK-MB methods but began to decline for myoglobin.

Negative_regulation (decline) of myoglobin

1) Confidence 0.42 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1458571 Disease Relevance 0.22 Pain Relevance 0.07

From starting Seiza, oxygenated hemoglobin/myoglobin decreased markedly and reached a plateau within about 6 min.

Negative_regulation (decreased) of myoglobin

2) Confidence 0.42 Published 2005 Journal J Hum Ergol (Tokyo) Section Abstract Doc Link 17393761 Disease Relevance 0.08 Pain Relevance 0.08

CONCLUSION: The data indicate that double layers of Farabloc fabric wrapped around the thigh reduces pain and strength loss and serum levels of malondialdehyde, creatine phosphokinase, myoglobin, leukocytes, and neutrophils when untrained human subjects are exposed to eccentric exercise to produce DOMS in the quadriceps.

Negative_regulation (reduces) of myoglobin in thigh

3) Confidence 0.39 Published 2000 Journal Clin J Sport Med Section Body Doc Link 10695845 Disease Relevance 0 Pain Relevance 0

These responses as well as plasma levels of creatine kinase and myoglobin were all attenuated after the repeated eccentric exercise bout (P < 0.05).

Negative_regulation (attenuated) of myoglobin in plasma

4) Confidence 0.34 Published 2008 Journal Eur. J. Appl. Physiol. Section Abstract Doc Link 18340456 Disease Relevance 0.10 Pain Relevance 0

The removal of myoglobin by plasma exchange has not demonstrated any benefit [145].

Negative_regulation (removal) of myoglobin in plasma

5) Confidence 0.21 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 1.55 Pain Relevance 0.03

Values of sodium, myoglobin and LDH decreased.

Negative_regulation (decreased) of myoglobin

6) Confidence 0.15 Published 2003 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 12894392 Disease Relevance 0 Pain Relevance 0

Because of different amounts of H-FABP and myoglobin in myocardial and skeletal muscle tissue a low mioglobin/H-FABP ratio might have myocardial specificity.

Negative_regulation (amounts) of myoglobin in skeletal muscle tissue

7) Confidence 0.07 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

This test has worked.