INT100601

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 13.61
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
Anatomy Link Frequency
brain 1
platelets 1
microglia 1
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 99.42 Very High Very High Very High
Inflammatory mediators 1 99.00 Very High Very High Very High
medulla 4 96.08 Very High Very High Very High
Hippocampus 35 88.96 High High
glial activation 1 86.76 High High
Spinal cord 37 86.00 High High
withdrawal 28 78.96 Quite High
imagery 12 68.88 Quite High
cINOD 4 54.24 Quite High
iatrogenic 12 52.08 Quite High
Disease Link Frequency Relevance Heat
Disease 266 100.00 Very High Very High Very High
Prion Diseases 143 100.00 Very High Very High Very High
Sleep Disorders 106 100.00 Very High Very High Very High
Creutzfeldt Jakob Disease 96 100.00 Very High Very High Very High
Neurodegenerative Disease 17 100.00 Very High Very High Very High
Chronic Fatigue Syndrome 226 98.94 Very High Very High Very High
INFLAMMATION 14 98.80 Very High Very High Very High
Kuru 208 98.44 Very High Very High Very High
Syndrome 6 97.48 Very High Very High Very High
Proteostasis Deficiencies 4 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abnormal PrP accumulation was examined using anti-PrP monoclonal ICSM 35 (D-Gen Ltd) followed by a biotinylated anti-mouse IgG secondary antibody (iView Biotinylated Ig, Ventana Medical Systems, Inc.) and an avidin–biotin horseradish peroxidase conjugate (iView SA-HRP, Ventana Medical Systems, Inc.) before development with 3?
Spec (examined) Localization (accumulation) of PrP
1) Confidence 0.66 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 0 Pain Relevance 0
Activated microglia and inflammatory mediators, including cytokines and prostaglandin E2 (PGE2) co-localize with PrP deposits.
Localization (co-localize) of PrP in microglia associated with inflammatory mediators and cytokine
2) Confidence 0.62 Published 2002 Journal Brain Res. Section Abstract Doc Link 11792368 Disease Relevance 0.42 Pain Relevance 0.32
Of the remaining cases, 1–2% is the infectious form acquired from an established source with the prion disease, 5–15% is familial autosomal dominant type inherited secondary to the mutation of prion protein gene localized on chromosome 20 [1].
Localization (localized) of prion protein associated with creutzfeldt jakob disease
3) Confidence 0.55 Published 2008 Journal Cases J Section Body Doc Link PMC2547099 Disease Relevance 1.00 Pain Relevance 0.06
By then the kuru epidemic had declined dramatically, but the advent of another TSE, bovine spongiform encephalopathy (BSE), and its oral transmission to humans to cause variant CJD (vCJD), led to a renewed global interest in kuru in the late 1990s.
Localization (cause) of CJD associated with creutzfeldt jakob disease, kuru and prion diseases
4) Confidence 0.54 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2577135 Disease Relevance 1.62 Pain Relevance 0
By then the kuru epidemic had declined dramatically, but the advent of another TSE, bovine spongiform encephalopathy (BSE), and its oral transmission to humans to cause variant CJD (vCJD), led to a renewed global interest in kuru in the late 1990s.
Localization (cause) of vCJD associated with creutzfeldt jakob disease, kuru and prion diseases
5) Confidence 0.54 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2577135 Disease Relevance 1.63 Pain Relevance 0
Considering that PRP can release factors involved in angiogenesis and the short effective time of platelets and its proteins, an angiogenic effect of PRP might be more important to promote bone healing in alloplastic bone substitutes.
Localization (release) of PRP in platelets
6) Confidence 0.41 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.09 Pain Relevance 0
This approach is supposed to overcome the short term effect of the PRP reported by previous study.13
Localization (reported) of PRP
7) Confidence 0.38 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.08 Pain Relevance 0
Because we simultaneously tested both positive and negative controls on the same plates, there was some, but obviously very low, potential for prion seeds to be inadvertently transferred from prion-seeded wells to adjacent negative control reactions.
Neg (negative) Localization (transferred) of prion-seeded
8) Confidence 0.37 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2996325 Disease Relevance 0.26 Pain Relevance 0
A detailed study of the brain damage in PGP-h1 sick animals showed neuropathological alterations typical of prion disease, including spongiform degeneration, astroglyosis and PrP accumulation (Fig. 4).
Localization (accumulation) of PrP in brain associated with prion diseases
9) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2675078 Disease Relevance 0.66 Pain Relevance 0.13
Recombinant prion protein induces a new transmissible prion disease in wild-type animals

Prion disease is a neurodegenerative malady, which is believed to be transmitted via a prion protein in its abnormal conformation (PrPSc).

Localization (conformation) of Prion associated with prion diseases and neurodegenerative disease
10) Confidence 0.11 Published 2010 Journal Acta Neuropathol Section Title Doc Link PMC2808531 Disease Relevance 0.82 Pain Relevance 0.08
Our studies establish that transmissible prion disease can be induced in wild-type animals by inoculation of rPrP and introduce a valuable new model of prion diseases.
Localization (disease) of prion associated with prion diseases
11) Confidence 0.11 Published 2010 Journal Acta Neuropathol Section Abstract Doc Link PMC2808531 Disease Relevance 0.79 Pain Relevance 0.09
To date, attempts to generate transmissible prion disease in wild-type animals using rPrPs have not been successful despite numerous attempts in which rPrP was converted into a broad array of abnormal ?
Localization (disease) of prion associated with prion diseases
12) Confidence 0.11 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2808531 Disease Relevance 0.82 Pain Relevance 0
Surprisingly, the current study suggests that transmissible prion disease can be induced by a preparation of rPrP fibrils, which appear to be fundamentally different with respect to their global structure from PrPSc.
Localization (disease) of prion associated with prion diseases
13) Confidence 0.11 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2808531 Disease Relevance 0.95 Pain Relevance 0
Their analyses, which included CFS subjects with sleep disorders identified by PSG and presence of insomnia, described the typical symptom and impairment profiles of the syndrome in CFS patients [14].
Localization (presence) of insomnia associated with chronic fatigue syndrome, syndrome and sleep disorders
14) Confidence 0.09 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2231384 Disease Relevance 1.98 Pain Relevance 0
Both CFS subjects and controls showed moderately impaired sleep quality (being in a research setting likely impaired sleep quality equally for both groups) and polysomnography is not an optimal measure of insomnia.
Localization (measure) of insomnia associated with chronic fatigue syndrome and sleep disorders
15) Confidence 0.09 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2231384 Disease Relevance 0.93 Pain Relevance 0
After a primary series of PRP-T at 2, 4, and 6 months of age and PRP-OMP vaccine at 2 and 4 months of age, infants with an anti-PRP antibody titer ?
Localization (vaccine) of PRP-OMP
16) Confidence 0.04 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610654 Disease Relevance 0.38 Pain Relevance 0
Bioethicists often argue that withdrawing any life-support treatment is morally and legally similar to withholding life-support treatment in the context of fatal disease at the end of life.
Localization (disease) of fatal associated with disease
17) Confidence 0.04 Published 2010 Journal BMC Med Ethics Section Body Doc Link PMC2949779 Disease Relevance 0.56 Pain Relevance 0.03
The question then becomes whether this ethical argument can be applied to a constitutive treatment with a medical device that is successfully treating a patient's fatal disease without the presence of any new lethal pathophysiological condition.
Localization (disease) of fatal associated with disease
18) Confidence 0.04 Published 2010 Journal BMC Med Ethics Section Body Doc Link PMC2949779 Disease Relevance 0.62 Pain Relevance 0

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