INT100606

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
plasma 2
liver 2
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 100.00 Very High Very High Very High
IPN 1 75.00 Quite High
Clonidine 6 59.24 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 100.00 Very High Very High Very High
Aging 4 98.72 Very High Very High Very High
Inflammatory Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PURPOSE: This study was designed to examine the effect of Freund's complete adjuvant (FCA)-induced inflammation on liver P450 expression and activities in the first 7 days that followed a single FCA injection in the rat hindpaw.
Spec (examine) Regulation (effect) of Gene_expression (expression) of P450 in liver associated with inflammation
1) Confidence 0.05 Published 2005 Journal Pharm. Res. Section Abstract Doc Link 15771231 Disease Relevance 0.17 Pain Relevance 0.12
Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: involvement of growth hormone-releasing factor and effects on cytochrome p450 expression.
Regulation (effects) of Gene_expression (expression) of p450 in plasma
2) Confidence 0.02 Published 2002 Journal Drug Metab. Dispos. Section Title Doc Link 11792682 Disease Relevance 0.09 Pain Relevance 0.06
During puberty, young adulthood, and senescence, changes in the hormonal profiles appear to be responsible for alterations in age-associated expression levels of selective P450 isoforms.
Regulation (alterations) of Gene_expression (expression) of P450 associated with aging
3) Confidence 0.01 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11792682 Disease Relevance 0.10 Pain Relevance 0

General Comments

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