INT10062

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.88
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB5) nucleoplasm (PSMB5) peptidase activity (PSMB5)
small molecule metabolic process (PSMB5) nucleus (PSMB5) cellular nitrogen compound metabolic process (PSMB5)
Anatomy Link Frequency
heart 1
PSMB5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thoracotomy 4 99.88 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 6 98.06 Very High Very High Very High
Angina 13 95.00 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 32 99.80 Very High Very High Very High
Coronary Artery Disease 2 97.76 Very High Very High Very High
Closed Head Injuries 1 96.32 Very High Very High Very High
Cv General 3 Under Development 8 95.00 High High
Convulsion 1 94.36 High High
Brain Injury 1 93.88 High High
Angina 5 92.16 High High
Injury 10 88.52 High High
Infarction 2 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CK-MB (relative index) and MB isoforms (MB2/MB1) were respectively increased in 15% and 75% of MI patients 1-6 h after onset, 94% and 94% after 7-12 h, and 88% and 8% after 12 h, and in 87% and 82% of cardiac surgery patients.
Positive_regulation (increased) of MB1 associated with myocardial infarction
1) Confidence 0.45 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1458574 Disease Relevance 1.38 Pain Relevance 0.16
After thoracotomy, MB2/MB1 was increased only in elderly patients (n = 5) with risk factors for ischemic heart disease; total CK-MB activity was increased in only three of these.
Positive_regulation (increased) of MB1 in heart associated with coronary artery disease and thoracotomy
2) Confidence 0.45 Published 1994 Journal Clin. Chem. Section Abstract Doc Link 8013097 Disease Relevance 0.22 Pain Relevance 0.25
Patients in the PTCA group showed an association between ischemic ST segment changes lasting > 3 min and a transient increase in the MB2/MB1 ratio; however, all had total CK-MB activity within normal limits.
Positive_regulation (increase) of MB1 associated with percutaneous transluminal coronary angioplasty
3) Confidence 0.45 Published 1994 Journal Clin. Chem. Section Abstract Doc Link 8013097 Disease Relevance 0.22 Pain Relevance 0.30
For elevated MB2/MB1 ratios there is a discrepancy between the MB2/MB1 ratios determined from the densitometric scans concerning the surface and the peak height ratios.
Positive_regulation (elevated) of MB1
4) Confidence 0.21 Published 1996 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 8981658 Disease Relevance 0.94 Pain Relevance 0.45
Worthy of note is the finding that in two acute myocardial infarction patients presenting MB2/MB1 ratios lower than the cutoff value (1.5) throughout the period of observation, the baseline values for carboxypeptidase N were higher than in other patients studied.
Positive_regulation (presenting) of MB1 associated with myocardial infarction
5) Confidence 0.21 Published 1997 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 9166972 Disease Relevance 0.63 Pain Relevance 0.09
MM3/MM1 and normal MB2/MB1 ratios show lower coefficients of variation than increased MB2/MB1 ratios.
Positive_regulation (increased) of MB1
6) Confidence 0.21 Published 1998 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 9587170 Disease Relevance 0.49 Pain Relevance 0.17

General Comments

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